{"product_id":"abcam-ab121285","title":"Abcam, ab121285, Anti-SLC51B antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal SLC51B antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC51B aa 50 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human SLC51B aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q86UW2\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSLC51B also known as OST-beta forms a heterodimer with SLC51A (OST-alpha) to function as an organic solute transporter involved in bile acid transport. This protein has a molecular mass of around 15 kDa. It is predominantly found in the ileum and liver key locations for bile acid circulation and metabolism. SLC51B localization to the basolateral membrane of enterocytes allows it to mediate transport across cellular barriers.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSLC51B plays an important role in enterohepatic circulation by facilitating the transport of bile acids and steroids. It works as part of a transporter complex when combined with OST-alpha enhancing transport efficiency. This function helps in maintaining bile acid homeostasis and supports lipid digestion and absorption. SLC51B's activity assists in controlling cholesterol levels and prevents the accumulation of toxic bile acid concentrations within cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe activity of SLC51B is integral to the enterohepatic bile acid recycling pathway and lipid metabolism pathways. It collaborates with proteins like NTCP and ASBT which are important for bile acid uptake in hepatocytes and enterocytes respectively. These pathways ensure efficient bile acid transport beginning from the liver its reabsorption in the intestines and return to the liver illustrating its central role in maintaining metabolic balance.\u003cbr\u003e\nSLC51B plays a significant part in conditions like cholestasis and inflammatory bowel disease (IBD). Its role in bile acid transport links it to cholestasis where bile flow is reduced and its dysfunction can exacerbate the disease. Furthermore it associates with proteins such as FXR which regulates bile acid homeostasis and impacts inflammatory pathways contributing to the pathology of IBD. Understanding the relationship of SLC51B in these disorders highlights potential areas for therapeutic intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850161803433,"sku":"ab121285","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab121285","provider":"Iright","version":"1.0","type":"link"}