{"product_id":"abcam-ab121446","title":"Abcam, ab121446, Anti-CALHM2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal CALHM2 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CALHM2 aa 100-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human CALHM2 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.Q9HA72\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCALHM2 also known as Calcium Homeostasis Modulator 2 functions mechanistically as an ion channel that mediates the permeability of calcium ions across the cell membrane. This protein has an approximate molecular mass of 37 kDa. CALHM2 is widely expressed in various tissues including the brain and heart. It is also part of a family of proteins known for their roles in modulating ion channel activity and maintaining calcium homeostasis within cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCALHM2 plays a role in the regulation of neuronal excitability and neurotransmitter release. This protein is known to form a complex with other CALHM family members where it influences cellular communication within the nervous system. CALHM2 is critical for maintaining the resting membrane potential and modulating the activity of neurons by impacting the flow of calcium and other ions which affects synaptic function.\u003cbr\u003e\nPathways\u003cbr\u003e\nCALHM2 participates in the calcium signaling pathway which is essential for various cellular processes. It interacts with other proteins such as CALHM1 a related family member to modulate ion permeability. CALHM2 is also involved in the neuronal signaling pathways where it contributes to synaptic plasticity and signal transduction which are essential for memory and cognitive functions.\u003cbr\u003e\nCALHM2 has associations with neurological disorders such as Alzheimer's disease as it influences calcium homeostasis and signaling in neurons. Disruptions in its function can lead to altered neuronal activity contributing to neurodegenerative conditions. CALHM2's interaction with proteins like amyloid-beta precursor protein (APP) connects its role to the pathology of Alzheimer's disease indicating a potential target for therapeutic intervention in such conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854166184105,"sku":"ab121446","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab121446","provider":"Iright","version":"1.0","type":"link"}