{"product_id":"abcam-ab121633","title":"Abcam, ab121633, Anti-NSUN5 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal NSUN5 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NSUN5 aa 100-250.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human NSUN5 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.Q96P11\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNSUN5 also known as NOL1\/NOP2\/Sun domain family member 5 is a methyltransferase enzyme responsible for the methylation of cytosine residues in RNA. It has an estimated mass of approximately 50 kDa. Researchers have found NSUN5 expressed in various tissues with significant levels observed in the liver brain and reproductive tissues. Its primary mechanical function facilitates the post-transcriptional modification of RNA influencing RNA stability and translation efficiency.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe methylation activity of NSUN5 contributes to cellular processes like RNA processing and gene expression regulation. NSUN5 forms part of the sub-complex associated with the large ribosomal subunit in eukaryotic cells. This connection suggests its role in ribosome biogenesis and protein synthesis. Studies also highlight NSUN5's involvement in safeguarding cell survival under stress by maintaining ribosomal RNA (rRNA) stability.\u003cbr\u003e\nPathways\u003cbr\u003e\nNSUN5 operates as an integral component in the ribosome biogenesis pathway and the RNA modification pathway. It interacts with other proteins such as NSUN2 and NSUN6 which share similar RNA methylation functions. These interactions suggest a cooperative mechanism among NSUN family members in ensuring proper RNA and ribosome functionality important under both normal and stress conditions.\u003cbr\u003e\nResearchers have linked NSUN5 to several health conditions including cancer and aging-related diseases. Elevated NSUN5 expression has been observed in various cancers proposing its role in tumorigenesis through dysregulation of cell growth control. Additionally its association with shortened human lifespan suggests an involvement in age-related changes through disrupted rRNA methylation. NSUN5's interaction with NSUN2 supports a complex network where alterations in RNA methylation contribute to disease development and progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850117238953,"sku":"ab121633","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab121633","provider":"Iright","version":"1.0","type":"link"}