{"product_id":"abcam-ab121718","title":"Abcam, ab121718, Anti-MSL1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal MSL1 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MSL1 aa 200-350.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human MSL1 aa 200-350. The exact immunogen used to generate this antibody is proprietary information.Q68DK7\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMSL1 or Male-Specific Lethal 1 functions mechanically as an important component of the MSL complex that engages in gene regulation activities. It has a molecular mass of approximately 62 kDa. MSL1 expresses in diverse tissues including the brain liver and muscle. It plays a critical role in dosage compensation contributing to equalizing gene expression levels between sexes in species like Drosophila.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMSL1 participates in the assembly of the MSL complex. This multi-protein complex facilitates histone H4 lysine 16 acetylation which activates transcription. MSL1 specifically assists in recruiting the acetyltransferase MOF to target sites on the X chromosome. The expression level and activity of MSL1 are tightly regulated to ensure proper chromosomal balance in the organism. Its activity is not limited to dosage compensation but also influences other chromatin remodeling processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nMSL1 plays significant roles in chromatin modification pathways participating in transcriptional regulation actively. The protein aligns closely with MOF in these pathways forming a duo that heavily influences acetylation across chromatin landscapes. In addition to histone modification MSL1 connections extend to gene expression pathways responding to various cellular stimuli interfacing with proteins like MSL2 and MSL3 to regulate gene activation machinery.\u003cbr\u003e\nMSL1 has associations with certain cancers including breast cancer and leukemia. The protein's dysregulation can skew chromatin remodeling leading to abnormal gene expression profiles commonly seen in tumorigenesis. MSL1 partners with other proteins like MOF impacting the transcriptional regulatory networks often targeted in cancer therapies. Understanding MSL1's role allows for targeted approaches in developing therapeutic strategies for these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850072182953,"sku":"ab121718","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab121718","provider":"Iright","version":"1.0","type":"link"}