{"product_id":"abcam-ab12174","title":"Abcam, ab12174, Anti-HDAC7 antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal HDAC7 antibody. Suitable for IP, WB, ICC\/IF and reacts with Human, Mouse, Rat samples. Cited in 19 publications. Immunogen corresponding to Synthetic Peptide within Human HDAC7 aa 400-500 conjugated to Keyhole Limpet Haemocyanin.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human, Rat,\u003cbr\u003e\nApplications:ICC\/IF, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human HDAC7 aa 400-500 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q8WUI4\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nStorage in frost-free freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-The antibody is affinity-purified using the immunizing peptide immobilized on agarose., Storage buffer-pH: 7.4Preservative: 0.097% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHistone deacetylase 7 (HDAC7) also known as HD7 or HD7A is a part of the class IIa histone deacetylases. It has a mass of approximately 103 kDa. HDAC7 plays a role in regulating gene expression by removing acetyl groups from lysine residues on histones leading to chromatin condensation and gene repression. This protein is expressed in various tissues including the heart skeletal muscle and T-cells where it influences diverse cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHDAC7 modulates transcription and affects cell differentiation and survival. It is a component of a larger protein complex working together with other proteins to influence transcription factor activity and chromatin architecture. It influences the expression of genes involved in immune responses as well as other critical cellular activities. By regulating these processes HDAC7 contributes to the balance between cell proliferation and apoptosis.\u003cbr\u003e\nPathways\u003cbr\u003e\nHDAC7 plays key roles in the Wnt signaling and T-cell receptor (TCR) signaling pathways. It interacts with other proteins such as HDAC3 and the nuclear receptor co-repressor (N-CoR) affecting pathway components and influencing cellular outcomes. In the Wnt pathway HDAC7's activity modifies the transcription of target genes impacting cell fate decisions. During TCR signaling HDAC7 aids in the regulation of T-cell development and function working closely with transcriptional factors involved in these pathways.\u003cbr\u003e\nHDAC7 has been associated with cancer and cardiovascular diseases. Its dysregulation can contribute to tumorigenesis through aberrant expression of genes controlling cell cycle and apoptosis. In cardiovascular disorders it impacts cardiac hypertrophy and heart failure due to its influence on heart-specific gene expression. HDAC7’s interaction with proteins like RUNX1 in T-cells can also contribute to the development of leukemia. These links highlight the importance of HDAC7 in both disease development and progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850102624425,"sku":"ab12174","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab12174","provider":"Iright","version":"1.0","type":"link"}