{"product_id":"abcam-ab121780","title":"Abcam, ab121780, Anti-TBC1D8B antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal TBC1D8B antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TBC1D8B aa 900-1100.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human TBC1D8B aa 900-1100. The exact immunogen used to generate this antibody is proprietary information.Q0IIM8\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTBC1D8B also known as TBC1 domain family member 8B acts as a GTPase-activating protein (GAP) that targets Rab GTPases. It weighs approximately 106 kDa. This protein aids in regulating endosomal trafficking processes. Human tissues show TBC1D8B expression particularly in the liver and kidney. Through its GAP activity TBC1D8B plays a role in vesicle transport systems within cells affecting how cellular materials are sorted and transported into lysosomes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTBC1D8B functions as an important regulator in cellular trafficking pathways affecting how cells manage internal transport processes. It does not exist as part of a larger known complex but independently influences endosomal sorting. By acting on Rab proteins it affects vesicular recycling and transport facilitating the correct targeting of proteins to their cellular destinations. These activities support critical cell signaling and maintenance functions at the molecular level.\u003cbr\u003e\nPathways\u003cbr\u003e\nTBC1D8B plays contributory roles in the regulation of the Ras-related protein Rab pathways and the endocytosis pathway. Rab GTPases like Rab11 work in conjunction with TBC1D8B to promote efficient recycling of endosomes. This is important for maintaining membrane dynamics and cellular homeostasis. Being part of these pathways TBC1D8B ensures that cellular surfaces are properly modified to respond to environmental signals.\u003cbr\u003e\nResearchers link TBC1D8B to focal segmental glomerulosclerosis (FSGS) and certain types of inherited kidney diseases. Mutations or malfunctions in TBC1D8B can lead to defective endosomal trafficking contributing to these conditions. Protein partners including nephrin and podocin relate to TBC1D8B in the context of FSGS emphasizing its role in maintaining kidney function and health. Understanding these connections may help in developing targeted therapies for related disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854215008425,"sku":"ab121780","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab121780","provider":"Iright","version":"1.0","type":"link"}