{"product_id":"abcam-ab122201","title":"Abcam, ab122201, Anti-KPRP antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal KPRP antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KPRP.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human KPRP. The exact immunogen used to generate this antibody is proprietary information.Q5T749\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze \/ thaw cycle, Store undiluted\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nKPRP also known as Keratinocyte Proline-Rich Protein or PGR9 is a structural protein involved in skin differentiation processes. This protein has a molecular weight of approximately 19 kDa. KPRP expression primarily occurs in the skin specifically in keratinocytes the predominant cell type in the epidermis. It plays a mechanical role in creating a protective barrier function of the skin by contributing to the formation of the cornified envelope the outermost layer of the skin.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nKPRP participates in skin homeostasis and barrier integrity. It interacts with other structural proteins to aid in the construction and maintenance of the cornified envelope. Although KPRP is not part of a known protein complex its role is significant in epidermal development and repair. It contributes to keratinocyte differentiation affecting the skin's ability to respond to external stressors.\u003cbr\u003e\nPathways\u003cbr\u003e\nKPRP is relevant in skin differentiation and barrier function processes. It is part of pathways related to epidermal development influencing normal skin desquamation. KPRP does not have direct involvement with major pathways like Wnt or Notch but indirectly supports various cascades that ensure efficient skin cell turnover and maturation. KPRP interacts with other proteins such as keratins to establish a resilient skin surface.\u003cbr\u003e\nKPRP has associations with skin-related conditions like psoriasis and dermatitis. Psoriasis causes changes in keratinocyte proliferation and differentiation where altered expression of KPRP may contribute to disease pathogenesis. Additionally in dermatitis KPRP plays a role in the skin's response to inflammation and environmental triggers. Its interaction with filaggrin another key skin protein provides insight into its involvement in maintaining barrier function and how disruptions can lead to or exacerbate these skin conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848526418089,"sku":"ab122201","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab122201","provider":"Iright","version":"1.0","type":"link"}