{"product_id":"abcam-ab122295","title":"Abcam, ab122295, Anti-FAM162A antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal FAM162A antibody. Suitable for IHC-P, ICC, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FAM162A.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-P, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human FAM162A. The exact immunogen used to generate this antibody is proprietary information.Q96A26\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFAM162A also known as protein family with sequence similarity 162 member A is a mitochondrial protein that plays a role in cellular apoptosis. It has a molecular mass of approximately 16-20 kDa. This protein is widely expressed in various tissues with notable expression in the heart brain and liver. FAM162A is an integral part of the mitochondrial inner membrane suggesting its involvement in mitochondrial-related processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFAM162A is involved in promoting apoptosis through the intrinsic mitochondrial pathway. It assists in the release of cytochrome c from mitochondria which then activates caspase cascades. FAM162A does not appear to function as part of a larger protein complex; rather it operates independently to exert its pro-apoptotic effects. Its expression levels increase in response to hypoxic conditions indicating a specific role in hypoxia-induced apoptosis.\u003cbr\u003e\nPathways\u003cbr\u003e\nFAM162A significantly impacts the apoptosis and hypoxia response pathways. In these pathways it interacts with proteins like cytochrome c and apoptosome components. Its action in the mitochondrial pathway suggests its role in regulating cell death in response to cellular stress making it an important component of the intrinsic apoptotic signaling pathway. FAM162A might also interplay with anti-apoptotic proteins such as Bcl-2 influencing the balance between cell survival and death.\u003cbr\u003e\nFAM162A is linked to neurodegenerative diseases like Alzheimer's and ischemic stroke. Its role in apoptosis especially under hypoxic conditions leads to neuronal cell death in these disorders. For instance FAM162A overexpression under hypoxia can worsen cellular damage in stroke by promoting unnecessary apoptosis. It is also connected with other apoptotic proteins such as caspase-3 an executor caspase which highlights its role in exacerbating neuronal death during pathologies associated with excessive apoptosis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860527534249,"sku":"ab122295","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab122295","provider":"Iright","version":"1.0","type":"link"}