{"product_id":"abcam-ab122345","title":"Abcam, ab122345, Anti-ARHGEF38 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal ARHGEF38 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ARHGEF38 aa 1-100.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human ARHGEF38 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9NXL2\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nARHGEF38 also known as Rho guanine nucleotide exchange factor 38 is a protein involved in influencing the Rho family of GTPases which play significant roles in various cellular processes. ARHGEF38 is a protein with an estimated molecular weight of around 75 kDa. It is expressed in various tissues with notable expression in the brain and spinal cord. It helps to regulate the conversion of GDP-bound inactive Rho GTPases to their active GTP-bound state aiding in cellular activities that rely on cytoskeletal reorganization.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nARHGEF38 functions in cellular mechanisms related to signal transduction and cytoskeletal dynamics. It is a component of protein complexes that drive these cellular responses. The protein mediates cell shape motility and interaction with the environment by activating Rho GTPases. It contributes to pathways that manage cellular structural organization and signal mediation essential for maintaining cellular communication and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe activities of ARHGEF38 are involved in the Rho GTPase cycle and the regulation of the actin cytoskeleton. The protein interacts with other GEFs and GAPs to regulate Rho GTPase activity levels. Key pathways include the Rho signaling pathway that impacts cellular structure and Wnt signaling that is important for development and cell fate decisions. ARHGEF38 influences these pathways through its modulation of the RhoA signaling cascade which connects it to other signaling proteins.\u003cbr\u003e\nAberrant regulation of ARHGEF38 contributes to certain neurological conditions. Its misfunction has been associated with neurodegenerative diseases such as Alzheimer's disease and psychiatric disorders including schizophrenia. ARHGEF38's interaction with other proteins in these pathways like the proteins Tau and DISC1 highlights its role in disease modulation. These links suggest that changes in ARHGEF38 function may disrupt cellular processes contributing to disease pathogenesis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854373736617,"sku":"ab122345","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab122345","provider":"Iright","version":"1.0","type":"link"}