{"product_id":"abcam-ab124717","title":"Abcam, ab124717, Anti-CD89 antibody [EPR4622(2)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal CD89 antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 5 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR4622(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCD89 also known as the Fc alpha receptor (FcαR) is a protein receptor with a molecular mass of approximately 55 to 75 kDa. It is encoded by the FCAR gene and predominantly expressed on myeloid cells such as neutrophils eosinophils monocytes and some macrophages. CD89 acts as an important component of the immune system by binding to the Fc region of immunoglobulin A (IgA) facilitating various immune responses. This receptor mediates diverse immune functions by activating cellular responses upon IgA ligand binding.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCD89 plays an important role in regulating immune surveillance and response. It associates with the gamma chain of the Fc receptor complex which is necessary for its signaling ability. The binding of IgA to CD89 triggers various processes including phagocytosis antibody-dependent cellular cytotoxicity (ADCC) and the release of pro-inflammatory cytokines. These processes are fundamental for host defense against pathogens particularly those entering through mucosal surfaces where IgA is typically abundant.\u003cbr\u003e\nPathways\u003cbr\u003e\nCD89 is part of the immune effector pathway and participates actively in the immunoregulatory signaling cascade. One significant pathway is the IgA-mediated immune response pathway where CD89 cooperates with other Fc receptors and integrins to clear infections. Additionally its interaction with the complement system enhances opsonization and pathogen elimination. Related proteins in these pathways include other Fc receptors like FcγR which share similar signaling mechanisms and immune functions.\u003cbr\u003e\nCD89 is associated with conditions involving dysregulated immune responses or infections. For example it is implicated in IgA nephropathy where abnormal IgA deposits in the kidneys may trigger inflammation through CD89-mediated pathways. Furthermore alterations in CD89 expression or function have been studied in the context of inflammatory bowel disease (IBD) illustrating the receptor's role in aberrant immune responses. The target’s interaction with proteins such as IgA and complement C3 provides insight into its involvement in these pathological conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850288156841,"sku":"ab124717","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab124717","provider":"Iright","version":"1.0","type":"link"}