{"product_id":"abcam-ab124879","title":"Abcam, ab124879, Anti-UGGT\/UGT1 antibody [EPR5105]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal UGGT\/UGT1 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 5 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR5105,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUGGT also known as UGT1 is a protein that catalyzes the addition of glucose to misfolded glycoproteins in the endoplasmic reticulum (ER). This enzyme weighs approximately 170 kDa and is found mainly in the ER. It functions by recognizing improperly folded proteins and facilitating their retention in the ER through tagging with a glucose moiety for quality control. The targeting of these proteins ensures only properly folded proteins proceed to the Golgi apparatus.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nUGGT\/UGT1 plays an important role in the cellular quality control system. It works as part of the calnexin cycle interacting with chaperones like calnexin and calreticulin which recognize the glycosylated proteins. This cycle ensures that proteins fold correctly before they leave the ER. If proteins remain misfolded UGGT\/UGT1 continues to add the glucose tag preventing their exit from the ER until correct folding occurs.\u003cbr\u003e\nPathways\u003cbr\u003e\nUGGT\/UGT1 is important for the proper functioning of the ER-associated degradation (ERAD) pathway and the unfolded protein response (UPR). In the ERAD pathway UGGT collaborates with proteins such as EDEM and mannosidase I recognizing and degrading misfolded glycoproteins. By doing so UGGT\/UGT1 helps maintain cellular homeostasis balancing protein synthesis and degradation within the ER environment to prevent stress and potential damage.\u003cbr\u003e\nUGGT\/UGT1 has connections to conditions like cystic fibrosis and certain congenital disorders of glycosylation. Cystic fibrosis involves improper protein folding where mutations lead to defective protein cycling and mismanagement of chloride channels like CFTR. In cases of congenital disorders of glycosylation UGGT\/UGT1 interacts with proteins involved in glycosylation processes leading to altered glycoprotein profiles with varied clinical outcomes. Understanding UGGT\/UGT1's interactions can aid in developing therapeutic strategies targeting protein misfolding.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850382135465,"sku":"ab124879","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab124879","provider":"Iright","version":"1.0","type":"link"}