{"product_id":"abcam-ab124881","title":"Abcam, ab124881, Anti-EPH A3+A4+A5 (phospho Y779 + Y779 + Y833) antibody [EPR5684]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Eph receptor A3 phospho Y779 antibody. Suitable for WB and reacts with Human, Rat, Mouse samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR5684,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:This antibody only detects EPH A3 phosphorylated at Tyrosine 779, EPH A4 phosphorylated at Tyrosine 779, and EPH A5 phosphorylated at Tyrosine 833.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEPH receptors A3 A4 and A5 which are also known as EPHA3 EPHA4 and EPHA5 are part of the receptor tyrosine kinase family. These proteins have a mass around 100-130 kDa. They predominantly express in neural tissues but one can also find them in certain epithelial and mesenchymal tissues. Functionally they play a role in cell-cell communication by binding with ephrin ligands which leads to kinase activation and downstream signaling cascades.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEPH receptors A3 A4 and A5 are essential for mediating a range of cellular processes including cell migration axon guidance and tissue boundary formation. They do not act in isolation but often form complexes with ephrin ligands such as ephrin-A1 and ephrin-A5. These interactions are critical in developmental processes and maintaining cellular architecture. By influencing cell positioning and movement they significantly contribute to nervous system development and vascular patterning.\u003cbr\u003e\nPathways\u003cbr\u003e\nEPH A3 A4 and A5 integrate into the ephrin signaling pathway and the integrin-mediated signaling pathway. In the ephrin signaling pathway they work in tandem with related proteins such as EPHA2 and EPHB receptors to modulate cellular dynamics. These pathways dictate cytoskeletal organization influencing cellular adhesion and motility impacting a variety of physiological processes including angiogenesis and nerve development.\u003cbr\u003e\nAltered functions of EPH A3 A4 and A5 associate with cancer and neurodegenerative diseases. In cancer especially glioblastoma and melanoma their overexpression or aberrant activity can lead to enhanced cell proliferation and metastasis partially through interactions with proteins like EPHA2. In neurodegenerative conditions such as Alzheimer's disease dysregulated EPH receptor signaling may contribute to neuronal death and cognitive impairment connected with proteins involved in tau pathologies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844215558313,"sku":"ab124881","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab124881","provider":"Iright","version":"1.0","type":"link"}