{"product_id":"abcam-ab125212","title":"Abcam, ab125212, Anti-CD68 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nAnti-CD68 antibody (ab125212) is a rabbit polyclonal antibody detecting CD68 in  Western Blot, IHC-P . Suitable for  Mouse, Rat . - Over 720 publications\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Mouse Cd68 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P31996\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAnti-CD68 antibody (ab125212) is a rabbit polyclonal antibody and is validated for use in IHC-Fr, IHC-P and WB.\u003cbr\u003e\nAnti-CD68 antibody (ab125212) was first used in a scientific publication in 2012 and has been cited over 726 times in peer reviewed journals. It's performance in Western blot, immunofluorescence and IHC in human, mouse and rat samples is trusted by the scientific community.\u003cbr\u003e\nAbcam's high quality validation processes ensure Anti-CD68 antibody (ab125212) has high sensitivity and specificity.\u003cbr\u003e\nAnti-CD68 antibody (ab125212) has 55 independent reviews from customers.\u003cbr\u003e\nAnti-CD68 antibody (ab125212) specifically detects CD68 (UniProt ID: P31996; Molecular weight: 33kDa) and is sold in 100 ug selling sizes.\u003cbr\u003e\nCD68 levels is implicated in autoimmune conditions like rheumatoid arthritis, where macrophages contribute to joint inflammation and damage. Cited in over 924 publications.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Constituents: 5.61% Trehalose, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCD68 is a glycoprotein that functions as a scavenger receptor. It plays an important role in the regulation of cellular debris and apoptotic cell clearance. Researchers often refer to it as KP1 or macrosialin in the literature. CD68 with a molecular weight of approximately 110 kDa is highly expressed in macrophages and monocytes. The mucin-like structure of CD68 allows it to be heavily glycosylated which aids in its function. Researchers detect CD68 in tissues through methods like immunohistochemistry (IHC) immunofluorescence and CD68 staining and it is widely used as a macrophage marker in research.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCD68 facilitates functions associated with the innate immune response. It serves as an important part of macrophages which contribute to immune surveillance and tissue homeostasis. Though it primarily operates on its own in some contexts CD68 might assist in forming complexes with other receptors to modulate phagocytic activity. This target is significant in atherosclerotic plaque stability as macrophages engulf lipids and cell debris through processes facilitated by CD68.\u003cbr\u003e\nPathways\u003cbr\u003e\nCD68 is involved in pathways connected to inflammation and phagocytosis. The CD68 protein works closely with other scavenger receptors like CD36 to mediate uptake of oxidized low-density lipoproteins (oxLDL) in the lipid metabolism pathway. Additionally CD68 engagement can influence the toll-like receptor (TLR) signaling pathways thereby linking innate immunity and inflammatory responses critical for host defense and disease progression.\u003cbr\u003e\nCD68 is associated with atherosclerosis and multiple sclerosis. In atherosclerosis its role becomes evident as it accumulates in macrophages within the plaques making it a marker of disease severity. In multiple sclerosis CD68 expression in macrophages and microglia indicates active demyelination and inflammation. It also relates to proteins such as CD36 in atherosclerosis where both mediate the uptake of modified LDL contributing to foam cell formation in plaques.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844219261097,"sku":"ab125212","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab125212","provider":"Iright","version":"1.0","type":"link"}