{"product_id":"abcam-ab126252","title":"Abcam, ab126252, Anti-Heat Shock Factor 2 Binding Protein antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal Heat Shock Factor 2 Binding Protein antibody. Suitable for IHC-P, WB and reacts with Mouse, Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HSF2BP aa 1-250.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human HSF2BP aa 1-250. The exact immunogen used to generate this antibody is proprietary information.O75031\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHeat Shock Factor 2 Binding Protein (HSF2BP) takes part in the regulation of heat shock response by interacting with Heat Shock Factor 2 (HSF2). It has a molecular mass of approximately 39 kDa. Expression of HSF2BP occurs mainly in testes though smaller amounts might be found in other tissues. HSF2BP directly associates with HSF2 altering its activity under stress conditions and regulates the transcription of heat shock proteins that protect cells from stress-induced damage.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHSF2BP modulates stress response mechanisms by influencing the availability of HSF2. It forms a complex with other proteins and regulates protein stability. This protein exerts control over the expression of genes involved in stress response and cellular protection. HSF2BP's activity equates to a regulatory checkpoint in the cellular stress response ensuring appropriate chaperone activity and protein folding.\u003cbr\u003e\nPathways\u003cbr\u003e\nHSF2BP intersects with the molecular chaperone network and the protein quality control pathways in cells. It interacts with pathways involving HSF2 and Heat Shock Factor 1 (HSF1) both critical for maintaining cellular integrity under stress conditions. HSF2BP influences these pathways by regulating the dynamic assembly of the transcription complex impacting gene expression profiles during stress response events.\u003cbr\u003e\nHSF2BP relates to reproductive and developmental health including infertility and neurodegenerative diseases. Aberrant expression or mutations in HSF2BP can disrupt the balance of cellular stress responses potentially contributing to disease states. Its interaction with HSF2 and HSF1 implicates it in disorders such as Alzheimer's where protein misfolding and stress response mechanisms are compromised. Understanding HSF2BP's role in these diseases could help to identify targets for therapeutic intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848590610601,"sku":"ab126252","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab126252","provider":"Iright","version":"1.0","type":"link"}