{"product_id":"abcam-ab126771","title":"Abcam, ab126771, Anti-Themis antibody [EPR7353]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Themis antibody. Suitable for ICC\/IF, IP, WB, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR7353,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), IP, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThemis also known as thymocyte-expressed molecule involved in selection is a protein involved in T-cell development. Themis has a mass of approximately 64 kDa. Researchers have found it expressed specifically in thymocytes a type of immune cell found in the thymus. Mechanically Themis helps in signal transduction processes necessary for the proper development and selection of T-cells which are important components of the adaptive immune system. Themis functions by binding to and modulating various signaling molecules within the immune cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThemis plays a significant role in T-cell receptor (TCR) signaling which is essential for the positive and negative selection of thymocytes. Themis functions as part of a complex that cooperates with other proteins to fine-tune the thresholds for TCR signaling. Through its action it ensures the proper development of functional and self-tolerant T-cells helping to distinguish self from non-self in immune responses. As cells progress through the thymus Themis regulates the strength and duration of signaling ensuring the appropriate intensity for T-cell maturation.\u003cbr\u003e\nPathways\u003cbr\u003e\nT-cell development heavily relies on Themis for its contribution to the TCR signaling pathway. Themis interacts in this pathway with important proteins such as LAT (Linker for Activation of T cells) and SLP-76 which are key components for propagating downstream signaling that leads to T-cell activation. Additionally Themis is involved with the Ras-MAPK signaling pathway which further contributes to cell proliferation and differentiation. Both pathways are critical for maintaining the balance in the immune response allowing for the selection of T-cells that can combat infections while avoiding autoimmunity.\u003cbr\u003e\nDisruptions in Themis function can link to autoimmune diseases and severe combined immunodeficiency (SCID). Mutations or misregulation of Themis can cause improper T-cell selection leading to the survival of self-reactive T-cells or failure in T-cell development. For example defective Themis activity has connections to autoimmune disorders where the body attacks its own tissues. In such cases proteins like LAT and SLP-76 can also show altered activity which contributes to the development and progression of these immune-related diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850294907049,"sku":"ab126771","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab126771","provider":"Iright","version":"1.0","type":"link"}