{"product_id":"abcam-ab127035","title":"Abcam, ab127035, Anti-LZTS1\/FEZ1 antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal LZTS1\/FEZ1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LZTS1 aa 300 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human LZTS1 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9Y250\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe LZTS1\/FEZ1 also known simply as LZTS1 functions as a tumor suppressor protein. Its gene encodes a leucine zipper putative tumor suppressor 1. LZTS1 has a molecular weight of approximately 67 kDa. This protein localizes mostly in the cytoplasm of cells and shows a specific expression pattern in a range of tissues including the prostate brain and lung. Its presence is noticeable in certain developmental stages and specific types of cells suggesting an important regulatory role in cellular functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nLZTS1 plays a significant role in cell cycle regulation and the inhibition of tumorigenesis. It does not typically form part of a complex but associates closely with other proteins to exert its effect. LZTS1 negatively regulates cell proliferation by interacting with cyclin-dependent kinase 1 (Cdk1) resulting in the inhibition of cell cycle progression from the G1 to S phase. This activity showcases its importance as a protective mechanism against uncontrolled cell division and cancer development.\u003cbr\u003e\nPathways\u003cbr\u003e\nLZTS1 integrates into important regulatory pathways specifically the cell cycle and apoptosis pathways. In the regulation of the cell cycle LZTS1 partners with proteins such as Cdk1 and is implicated in the careful orchestration of cell division. In the apoptotic pathway while LZTS1 itself may not directly induce apoptosis its influence on cell cycle arrest can indirectly promote apoptosis representing a link to protein interactions that involve p53-mediated pathways.\u003cbr\u003e\nLZTS1 has a significant connection to various cancers including prostate cancer and lung cancer. The reduced expression or mutation of LZTS1 is often observed in these malignancies hinting at a loss of its tumor-suppressing capabilities. Additionally LZTS1 interacts with proteins like β-catenin in colorectal cancer indicating its involvement in the Wnt signaling pathway dysregulation seen in these disorders. The study of LZTS1's role in such diseases aids in the understanding and potential development of targeted cancer therapies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854349783209,"sku":"ab127035","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab127035","provider":"Iright","version":"1.0","type":"link"}