{"product_id":"abcam-ab127108","title":"Abcam, ab127108, Recombinant Human PI 3 Kinase p55 gamma protein","description":"\u003cp\u003eSize: 20µg \/ 50µg\u003cbr\u003e\nRecombinant Human PI 3 Kinase p55 gamma protein is a Human Full Length protein, in the 1 to 461 aa range, expressed in Baculovirus infected Sf9 cells, with \u0026gt;80%, suitable for SDS-PAGE, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;80% SDS-PAGE,\u003cbr\u003e\nExpression system:Baculovirus infected Sf9 cells,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q92569,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7Preservative: 1.02% ImidazoleConstituents: 25% Glycerol (glycerin, glycerine), 1.76% Sodium chloride, 0.07% Sodium phosphate, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.002% PMSF\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPI 3 Kinase p55 gamma also known as PIK3R3 is a regulatory subunit of the PI 3-kinase complex. It is a component of the heterodimeric enzyme which includes a catalytic subunit class I and this regulatory subunit. Its molecular mass is around 50-60 kDa. The p55 gamma protein is highly expressed in tissues such as the brain and skeletal muscles. It plays a significant role in intracellular signaling processes mediated by various extracellular signals.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe p55 gamma protein acts as part of the phosphoinositide 3-kinase (PI3K) complex. This complex transmits signals from growth factors and cytokines contributing to the regulation of cell growth survival and metabolism. The p55 form functions as a regulatory subunit influencing the kinase activity of the catalytic counterpart. It is often found in association with activated receptor tyrosine kinases (RTKs) and aids in the recruitment of the catalytic subunit to the plasma membrane.\u003cbr\u003e\nPathways\u003cbr\u003e\nPI 3 Kinase p55 gamma participates in the PI3K\/AKT signaling pathway and the insulin signaling pathway. These pathways are critical for regulating metabolic activities cell growth and survival. It often regulates the activity of AKT also known as Protein Kinase B which in turn affects several downstream signaling proteins and pathways.\u003cbr\u003e\nThe PI 3 Kinase p55 gamma has associations with cancer and insulin resistance due to its role in cell proliferation and metabolic pathways. Abnormal signaling and mutations affecting p55 gamma can lead to oncogenic processes and altered insulin metabolism. The target's interaction with proteins such as AKT makes it a point of interest in understanding cancer pathogenesis and diabetic conditions as disruptions in its signaling can result in abnormal growth and insulin response.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843967471785,"sku":"ab127108","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab127108","provider":"Iright","version":"1.0","type":"link"}