{"product_id":"abcam-ab129166","title":"Abcam, ab129166, Anti-NCS1 antibody [EPR7699]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal NCS1 antibody. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human, Rat, Mouse samples. Cited in 6 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR7699,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe target 'NCS1' also known as Neuronal Calcium Sensor 1 is a small protein with a mass of approximately 22 kDa. This protein binds calcium ions and plays an important role in calcium signaling pathways. It is broadly expressed in neuronal tissues where it assists in regulating neurotransmitter release and synaptic plasticity. NCS1 belongs to a family of calcium-binding proteins characterized by EF-hand motifs which allow calcium ion attachment and subsequent conformational changes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNCS1 modulates intracellular calcium concentrations which are critical for numerous cellular functions. It interacts with various signaling proteins and receptors impacting cell signaling and communication. NCS1 does not operate alone but functions as part of larger protein complexes which modulate its activity and extend its biological roles. Its involvement supports neuronal processes like growth and differentiation by modulating the effect of calcium signals within the nerve cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nNCS1 plays a role in the phosphoinositide signaling pathway and the regulation of calcium homeostasis. It works alongside proteins such as phosphatidylinositol 4-kinase III beta (PI4KB) to maintain the balance of calcium in cells. NCS1 participation in signaling pathways ensures that calcium influx and release from intracellular stores happen efficiently which is essential for the transmission of signals across synapses.\u003cbr\u003e\nNCS1 is associated with neurological conditions such as schizophrenia and bipolar disorder. Alterations in NCS1 expression or function can affect calcium signaling leading to disruptions in neuronal communication and function. Furthermore NCS1 interacts with dopamine receptor D2 (DRD2) which is significant in the development of these psychiatric conditions. Understanding the role of NCS1 in these disorders can provide insights into potential therapeutic targets for managing such diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844205727913,"sku":"ab129166","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab129166","provider":"Iright","version":"1.0","type":"link"}