{"product_id":"abcam-ab129879","title":"Abcam, ab129879, Anti-GPR 139 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal GPR 139 antibody. Suitable for ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GPR139.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human GPR139. The exact immunogen used to generate this antibody is proprietary information.Q6DWJ6\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab129879 is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen., Storage buffer-pH: 7Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGPR139 known also as G protein-coupled receptor 139 is a member of the rhodopsin family of G protein-coupled receptors (GPCRs). It has an approximate mass of 37 kDa. This receptor mainly expresses in the central nervous system specifically in the thalamus habenula and hypothalamus. It is part of the larger group of products encoded by GPCR genes which play significant roles in signal transduction across cell membranes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGPR139 acts as a modulator within the brain's neurochemical network. Although not part of a larger complex it influences neurotransmitter systems by transducing extracellular signals through intramembrane effects affecting physiological processes like mood circadian rhythms and pain perception. Researchers continue to explore its ligands such as L-tryptophan and L-phenylalanine which may provide further insight into its specific regulatory roles.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe functionality of GPR139 intersects with neuronal signaling pathways like the cAMP signaling pathway. This pathway impacts cellular processes by modulating enzymes and transcription factors relevant to intracellular signaling. GPR139's activity also relates to that of other GPCRs such as GPR88 which influences similar neurological functions and developmental pathways in neurons.\u003cbr\u003e\nGPR139 is mainly associated with neurological disorders and mental health conditions. Some studies link it to addiction and schizophrenia as it interacts with systems that regulate mood and reward. Through its association with dopamine D2 receptors GPR139 might influence disorders related to dopaminergic function offering a potential target for therapeutic interventions in these areas.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850072019113,"sku":"ab129879","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab129879","provider":"Iright","version":"1.0","type":"link"}