{"product_id":"abcam-ab130403","title":"Abcam, ab130403, Anti-Spir-1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal Spir-1 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SPIRE1 aa 350-500.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human SPIRE1 aa 350-500. The exact immunogen used to generate this antibody is proprietary information.Q08AE8\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nStore product undiluted. For continuous use, store at 2-8°C for one-two days. Working dilution samples should be discarded if not used within 12 hours. The antibody solution should be gently mixed before use.\u003cbr\u003e\nThis antibody is mono-specific.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSpir-1 also known as SPIR1 is a protein that functions as an actin nucleator. Its molecular mass is approximately 82 kDa. Spir-1 polymerizes actin by initiating the formation of new actin filaments. It has a role in controlling cytoskeletal dynamics important for cellular structure and movement. Spir-1 is expressed in a variety of human tissues including the brain where it shows particular activity in embryonic and neural tissues. These actin-modulating properties contribute to its regulation of cellular processes fundamental for organismal development.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSpir-1 influences the organization of the actin cytoskeleton acting as an important factor in cellular motility and shape determination. It forms a complex with other actin-related proteins such as the formin protein family. This complex enables Spir-1 to work efficiently in actin polymerization ensuring the proper assembly of actin filaments. Spir-1's role becomes critical during processes like cell division and intracellular transport where actin dynamics are essential.\u003cbr\u003e\nPathways\u003cbr\u003e\nSpir-1 participates in the regulation of the actin cytoskeleton pathway integral for maintaining cellular architecture and facilitating intracellular transport. Spir-1 closely interacts with proteins like formin homology proteins to control actin dynamics within this pathway. Another important pathway where Spir-1 is active is the signal transduction pathway which involves communication within cells to coordinate responses to external signals influencing how cells change their behavior or state in reaction to environmental cues.\u003cbr\u003e\nSpir-1 has associations with neurodevelopmental disorders and cancer. Disruptions in actin dynamics influenced by aberrant Spir-1 function may lead to impaired neural development linking it to developmental brain disorders. Additionally anomalous Spir-1 activity could contribute to cancer progression as changes in cytoskeleton organization can affect cell proliferation and movement elements important for tumor growth and metastasis. Proteins such as cortactin another actin-associated protein also tie into these disease processes highlighting the complex network of actin regulatory proteins in disease states.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854120767657,"sku":"ab130403","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab130403","provider":"Iright","version":"1.0","type":"link"}