{"product_id":"abcam-ab131035","title":"Abcam, ab131035, Anti-HGD antibody [EPR7874]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal HGD antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR7874,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHGD also known as homogentisate oxidase is an important enzyme involved in the catabolism of aromatic amino acids like tyrosine and phenylalanine. This enzyme possesses a molecular mass of roughly 50 kDa. In the human body HGD is expressed predominantly in the liver and kidney tissues. Its primary role is to catalyze the conversion of homogentisic acid into maleylacetoacetic acid a vital step in the breakdown process of these amino acids.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe role of HGD is essential in maintaining proper amino acid metabolism. It does not directly form part of larger enzymatic complexes but acts as a standalone enzyme that facilitates a specific reaction in the breakdown pathway. This specific reaction aids in preventing the accumulation of intermediary metabolites that could cause cellular toxicity. By regulating the levels of homogentisic acid HGD ensures cellular homeostasis is maintained.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe function of HGD fits into several metabolic processes related to amino acid degradation. Most notably it operates within the tyrosine degradation pathway a critical series of reactions required for energy production and detoxification in the body. HGD activity is intricately linked with enzymes like tyrosine aminotransferase which helps initiate the tyrosine breakdown and fumarylacetoacetate hydrolase which serves in the terminal steps of this pathway.\u003cbr\u003e\nImproper functioning of HGD is directly associated with alkaptonuria a rare hereditary disorder causing the accumulation of homogentisic acid in body tissues. This condition often leads to arthritic complications and kidney stones. The dysfunction of this enzymatic pathway can also indirectly affect vitamin D metabolism highlighting the importance of HGD's efficient operation. In alkaptonuria the insufficient activity of HGD leads to an elevation of homogentisic acid affecting downstream pathways and interacting proteins critical for maintaining skeletal and renal health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850384625833,"sku":"ab131035","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab131035","provider":"Iright","version":"1.0","type":"link"}