{"product_id":"abcam-ab131504","title":"Abcam, ab131504, Anti-MK2 (phospho T334) antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal MK2 phospho T334 antibody. Suitable for IHC-P, ICC\/IF, WB and reacts with Human, Mouse samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human MAPKAPK2 phospho T334 conjugated to Keyhole Limpet Haemocyanin.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human MAPKAPK2 phospho T334 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P49137,\u003cbr\u003e\nSpecificity:ab131504 detects endogenous levels of MK2 only when phosphorylated at threonine 334. The immunogen sequence used to produce ab131504 is 90% identical to the corresponding region of MAPKAP Kinase 3MK3, therefore ab131504 may cross react with human MK3 but this has not been confirmed.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab131504 was purified by affinity chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatography using non-phosphopeptide., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe MK2 protein also known as mitogen-activated protein kinase-activated protein kinase 2 or MAPKAPK2 is an important enzyme involved in cellular signaling. MK2 has a protein mass of approximately 44 kDa. It is widely expressed in various tissues indicating its broad functional roles. MK2 interacts with MAP kinases facilitating the transmission of signals within cells during stress responses and inflammation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMK2 plays an important role in the cellular stress response by regulating cytokine production particularly in inflammation. It acts as part of a protein complex with p38 MAPK enhancing its kinase activity. This interaction allows MK2 to control the expression of inflammatory cytokines and other stress-responsive proteins. The complex also responds to cellular stress signals allowing it to modulate gene expression effectively.\u003cbr\u003e\nPathways\u003cbr\u003e\nMK2 contributes to the p38 MAPK signaling pathway a major route for stress and inflammatory responses in cells. MK2 often interacts with related proteins like p38 MAPK which are directly upstream in the signaling cascade. Additionally MK2 is involved in the post-transcriptional regulation of mRNA stability and translation interfacing with the NF-kB signaling pathway highlighting its regulatory role in inflammation.\u003cbr\u003e\nMK2's role in inflammation links it to numerous inflammatory diseases such as rheumatoid arthritis and Crohn's disease. MK2's interaction with other proteins like p38 MAPK and downstream effectors such as transcription factors emphasizes its therapeutic potential. Targeting MK2 and its interaction with these proteins may offer novel treatments for conditions characterized by dysregulated inflammatory responses.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854151012521,"sku":"ab131504","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab131504","provider":"Iright","version":"1.0","type":"link"}