{"product_id":"abcam-ab131707","title":"Abcam, ab131707, Recombinant human CASK protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant human CASK protein is a Human Fragment protein, in the 1 to 564 aa range, expressed in Baculovirus infected Sf9 cells, with \u0026gt;95%, suitable for SDS-PAGE, WB, FuncS.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;95% SDS-PAGE,\u003cbr\u003e\nExpression system:Baculovirus infected Sf9 cells,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, WB, FuncSSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:Yes,\u003cbr\u003e\nBiological activity:The specific activity of ab131707 was determined to be 3 nmol\/min\/mg.,\u003cbr\u003e\nAccession:O14936,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.005% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab204874\u003cbr\u003e\n(PKI-alpha peptide) can be utilized as a substrate for assessing kinase activity\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCASK also known as calcium\/calmodulin-dependent serine protein kinase is a multifunctional protein with approximately 112 kDa mass. It is involved in intracellular signaling and synaptic function. CASK mainly localizes at the cell membrane but also exists in the cytoplasm and nucleus. This protein widely expresses in the brain and various tissues including the kidney and heart. Its alternative name includes LIN-2 which refers to its homolog in C. elegans.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCASK acts as a scaffold protein facilitating protein interactions and signal transduction. It forms part of larger complexes such as the MAGUK family supporting the stability and function of cell adhesion molecules. CASK interacts with proteins like neurexins and leukocyte common antigen-related family proteins playing an important role in synaptic formation and maintenance. Its activity involves phosphorylation which impacts neural development mechanisms.\u003cbr\u003e\nPathways\u003cbr\u003e\nOne can find CASK within the neuronal signaling and cell adhesion pathways. It serves a role in neurotransmission processes and synaptic plasticity closely interacting with proteins like neurexin and Mint1. CASK participates in the arrangement of synaptic vesicle exocytosis and influences synaptic strength. As a scaffold it integrates signals from different pathways enabling a coordinated cellular response.\u003cbr\u003e\nAbnormalities in CASK expression or function link to neurological disorders such as mental retardation and epilepsy. Mutations in the CASK gene may lead to a disorder known as mental retardation and microcephaly with pontine and cerebellar hypoplasia (MICPCH) characterized by developmental issues in brain structure. Moreover CASK dysfunction can relate to autism spectrum disorders where it interacts with proteins like neurexin affecting synaptic connectivity and transmission.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843833155753,"sku":"ab131707","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab131707","provider":"Iright","version":"1.0","type":"link"}