{"product_id":"abcam-ab132194","title":"Abcam, ab132194, Recombinant Human Synaptogyrin 2 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human Synaptogyrin 2 protein is a Human Full Length protein, in the 1 to 224 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:O43760,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSynaptogyrin 2 also known as SYNGR2 is a membrane protein with a known molecular weight of approximately 26.5 kDa. It is a component of the synaptogyrin family which consists of proteins located in neuronal and endocrine tissues. Synaptogyrin 2 is a tetraspan membrane protein found in the vesicles of presynaptic neurons where it plays a role in modulating neurotransmitter release at the synapse. Its presence is prominent in the brain as well as in other nerve tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein contributes to the regulation of synaptic transmission. Synaptogyrin 2 does not act alone; instead it interacts with other proteins forming a complex that helps in managing the availability and recycling of synaptic vesicles. This regulation is significant for maintaining neurotransmitter homeostasis in neural communication influencing synaptic plasticity and overall brain function.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe function of Synaptogyrin 2 relates to the synaptic vesicle cycle and the neurotransmitter release pathway. It closely associates with proteins like synaptophysin and synaptotagmin which are essential for the process of synaptic vesicle exocytosis and endocytosis. Through these pathways Synaptogyrin 2 impacts the efficiency and fidelity of neurotransmission which are critical features of neuronal communication.\u003cbr\u003e\nImpairments involving Synaptogyrin 2 affect neurological functions linking it to disorders such as schizophrenia and epilepsy. Its interaction with proteins like SNAP-25 and syntaxin emphasizes its role in ensuring proper synaptic transmission. Abnormalities in these interactions may lead to altered synaptic function contributing to the pathophysiology of these conditions. Understanding Synaptogyrin 2’s role in these disorders aids in developing targeted therapeutic approaches.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843885977769,"sku":"ab132194","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab132194","provider":"Iright","version":"1.0","type":"link"}