{"product_id":"abcam-ab132296","title":"Abcam, ab132296, Recombinant Human EFHD2\/SWS1 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human EFHD2\/SWS1 protein is a Human Full Length protein, in the 1 to 240 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:Tag free,\u003cbr\u003e\nApplications:ELISA, SDS-PAGE, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q96C19,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEFHD2 also known as SWS1 is a calcium-binding protein with a mass of approximately 25 kilodaltons. It has an EF-hand motif that facilitates interaction with calcium ions playing a role in actin cytoskeleton dynamics. EFHD2 expresses in several tissues particularly in the brain immune cells and certain cancer cell lines. Its presence in these tissues suggests diverse roles ranging from neurotransmission to immune response modulation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein participates in cell communication and signaling. It serves an important function in various cellular processes and is a component of the neuronal signalosome complex. EFHD2 interacts with actin filaments and influences cell morphology and migration especially in neurons. It also modulates neuronal plasticity affecting learning and memory processes by impacting synaptic activity and stability.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe protein EFHD2 is involved in the calcium signaling pathway which is important for cellular responses and adaptations to external signals. It connects with proteins like CAMKII and calcineurin in this pathway modulating their activity. EFHD2 also participates in the immune signaling cascade partnering with proteins such as SLP-76 and VAV to regulate immune cell activation and function.\u003cbr\u003e\nEFHD2 has links to neurodegenerative diseases like Alzheimer's and immune-related conditions such as rheumatoid arthritis. In Alzheimer's disease modifications in EFHD2 influence tau protein dynamics contributing to neurofibrillary tangle formation. The protein's dysregulation in rheumatoid arthritis affects NF-kB signaling altering the inflammation response. Overall EFHD2's activity and interactions with other proteins are significant in understanding these disorders' pathophysiology.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843875295401,"sku":"ab132296","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab132296","provider":"Iright","version":"1.0","type":"link"}