{"product_id":"abcam-ab132637","title":"Abcam, ab132637, Recombinant Human EDC3 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human EDC3 protein is a Human Full Length protein, in the 1 to 508 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q96F86,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe EDC3 protein also known as Enhancer of mRNA Decapping 3 serves an essential role in mRNA processing and turnover. It functions mechanically within the RNA decay pathway aiding in the removal of the cap structure from mRNA a step important for mRNA degradation. EDC3 with a molecular mass of approximately 59 kDa is expressed in various tissues notably in brain and testis among others. It interacts with multiple RNA-binding proteins that support the assembly of mRNA decay machinery.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEDC3 supports mRNA regulation by participating in mRNA decapping a regulatory process essential for controlling gene expression. EDC3 is a critical component of the decapping complex interacting with proteins like DCP1 and DCP2 facilitating efficient decapping of mRNA. The interaction of EDC3 with Pat1 another decapping activator enhances the mRNA decay process and ensures proper turnover of mRNA in the cell.\u003cbr\u003e\nPathways\u003cbr\u003e\nEDC3 plays a part in the 5' to 3' mRNA decay pathway facilitating the removal of the cap structure leading to exonucleolytic degradation of mRNA. This pathway is important in mRNA degradation and turnover ensuring precise regulation of gene expression. EDC3 is related to proteins such as LSM1 and XRN1 which cooperate within the 5' to 3' exonucleolytic decay pathway promoting efficient mRNA degradation.\u003cbr\u003e\nEDC3 alterations may associate with neurological conditions and cancer. Studies suggest that disruptions in mRNA decay where EDC3 plays a central role can lead to improper gene expression contributing to neuronal dysfunctions in neurological diseases. Also anomalies in decay pathways may link to oncogenic processes potentially pointing to EDC3's involvement in cancer development. EDC3’s interaction with proteins like DCP2 and XRN1 in the context of these disorders reveals the significance of RNA processing in maintaining cellular homeostasis and preventing disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843887780009,"sku":"ab132637","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab132637","provider":"Iright","version":"1.0","type":"link"}