{"product_id":"abcam-ab133496","title":"Abcam, ab133496, Anti-Cytokeratin 19 antibody [EPNCIR127B]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nAnti-Cytokeratin 19 antibody [EPNCIR127B] (ab133496) is a rabbit monoclonal antibody detecting Cytokeratin 19 in  Western Blot, IHC-P . Suitable for  Mouse . - Biophysical QC for unrivalled batch-batch consistency - Over 60 publications\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPNCIR127B,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-Cytokeratin 19 antibody [EPNCIR127B] (ab133496) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Mouse samples.\u003cbr\u003e\nWhat is the molecular weight of Cytokeratin 19?\u003cbr\u003e\nAnti-Cytokeratin 19 [EPNCIR127B] (ab133496) specifically detects a band for Cytokeratin 19 (UniProt: P08727) at a molecular weight of 44kDa.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-Cytokeratin 19 [EPNCIR127B] (ab133496) was first used in a scientific publication in 2012 and has been cited over 60 times in peer-reviewed journals.\u003cbr\u003e\nTrial sizes available!\u003cbr\u003e\nTest your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.\u003cbr\u003e\nDiscover our selection of trial-size antibodies\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [EPNCIR127B] also available for your convenience: ab133496, Carrier free -\u003cbr\u003e\nab233174\u003cbr\u003e\n, Alexa Fluor® 488 -\u003cbr\u003e\nab311036\u003cbr\u003e\n, Alexa Fluor® 647 -\u003cbr\u003e\nab311162\u003cbr\u003e\n, Alexa Fluor® 594 -\u003cbr\u003e\nab311812\u003cbr\u003e\n, Alexa Fluor® 568 -\u003cbr\u003e\nab313095\u003cbr\u003e\n, Alexa Fluor® 555 -\u003cbr\u003e\nab313288\u003cbr\u003e\n, Alexa Fluor® 750 -\u003cbr\u003e\nab321048\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nHuman, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle|Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCytokeratin 19 (CK19) also known as cytokeratine 19 keratin 19 (KRT19) or CK19 is a type of intermediate filament found in epithelial cells. It serves as an essential component of the cytoskeleton. CK19 weighs approximately 40 kDa and is broadly expressed in simple epithelial tissues including liver intestine and various glandular epithelial cells. As a cytokeratin marker it often appears in combination with others like cytokeratin 17 in certain tissue types helping to maintain the structural integrity of cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCK19 plays a role in maintaining the cytoskeletal framework that provides mechanical support and helps control cell size and shape. It is not part of a large protein complex but works closely with other cytokeratins to ensure the stability and resilience of epithelial tissues. The A53-B\/A22.26 positive staining is often used to confirm its presence in clinical histopathology.\u003cbr\u003e\nPathways\u003cbr\u003e\nCK19 connects to cellular processes especially involving the keratinization and epithelial cell differentiation pathways. It interacts with other cytokeratins including BA16 and KR17 to facilitate these processes. This interaction aids in modulating the dynamics of cytoskeletal rearrangement during cell movement division and differentiation.\u003cbr\u003e\nCK19 overexpression is linked with certain cancers notably hepatocellular carcinoma and breast cancer. It can serve as a prognostic marker in these diseases often in conjunction with other markers like CK17. The involvement of CK19 in the epithelial-mesenchymal transition (EMT) process connects it to the progression and aggressiveness of tumors facilitated by interactions with proteins involved in EMT pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844060926121,"sku":"ab133496","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab133496","provider":"Iright","version":"1.0","type":"link"}