{"product_id":"abcam-ab133634","title":"Abcam, ab133634, Anti-Caspr antibody [EPR7828]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Caspr antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human, Rat, Mouse samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR7828,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCaspr also known as contactin-associated protein 1 (CNTNAP1) is a transmembrane protein important for axonal function. It is approximately 190 kDa in size. Caspr is expressed mainly in neurons specifically at the paranodal regions of myelinated axons. This location is important for nerve impulse propagation demonstrating its structural and functional roles in the nervous system.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCaspr interacts with other proteins at the paranodes forming a complex with contactin and Neurofascin 155. This complex contributes to the insulation and maintenance of the nerve's myelin sheath. By ensuring proper node of Ranvier organization Caspr supports efficient saltatory conduction. The protein's interaction within these complexes allows axons to transmit signals rapidly and accurately.\u003cbr\u003e\nPathways\u003cbr\u003e\nCaspr plays an important role in the maintenance of nervous system architecture and function. It is integral to the axoglial junctions and participates in the clustering and distribution of ion channels which are essential components of the nervous system. Caspr regulates these processes by interacting with proteins such as contactin and Neurofascin facilitating the communication and signaling pathways necessary for nervous system homeostasis.\u003cbr\u003e\nCaspr dysfunction is linked to conditions such as multiple sclerosis and hereditary neuropathies. Abnormalities in Caspr or its associated complexes can lead to myelination defects and impaired nerve transmission. The protein's involvement in these diseases often relates to its association with contactin and other neuronal proteins highlighting its significance not only in healthy nervous system function but also in pathologies that affect nerve conduction.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844165914793,"sku":"ab133634","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab133634","provider":"Iright","version":"1.0","type":"link"}