{"product_id":"abcam-ab133691","title":"Abcam, ab133691, Anti-HOOK2 antibody [EPR8673]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal HOOK2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR8673,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHOOK2 also known as \"hook II\" is a protein involved in microtubule binding and anchoring of cytoplasmic organelles. It has a molecular mass of approximately 85 kDa. HOOK2 is expressed in various tissue types including brain and testis and localizes to specific cell structures like the cytoplasm and centrosomes. This protein helps organize the microtubule network which is critical for maintaining cellular architecture and intracellular transport processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHOOK2 plays a role in cellular processes through its involvement in the Hook protein family known for coordinating endosome dynamics. HOOK2 forms part of the dynein-dynactin complex where it links organelles to the microtubule network facilitating directed movement. This protein is essential for endosome positioning and possibly involved in ciliary function through its tethering role. It modulates the interactions with motor proteins and other accessory components necessary for cellular trafficking.\u003cbr\u003e\nPathways\u003cbr\u003e\nHOOK2's function integrates into the intracellular transport and cilia assembly pathways. It associates with proteins like dynein a motor protein that moves along microtubules to mediate transport within cells. In the ciliogenesis pathway HOOK2 participates in the extension and maintenance of cilia small hair-like structures important for cell signaling. The precise coordination in these pathways is important for cell communication and maintaining cellular homeostasis.\u003cbr\u003e\nHOOK2 has connections to certain neurodegenerative diseases and ciliopathies due to its role in microtubule dynamics and cilia formation. Aberrations in HOOK2 function can disrupt cellular transport mechanisms leading to neurological disorders such as Alzheimer's disease. Altered interactions with proteins like dynein in ciliopathy contexts can result in defects in ciliary function impacting cellular signaling pathways and contributing to disease pathology. Understanding HOOK2’s interactions in these processes provides insights into its role in health and disease.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844241379497,"sku":"ab133691","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab133691","provider":"Iright","version":"1.0","type":"link"}