{"product_id":"abcam-ab133786","title":"Abcam, ab133786, Anti-Transglutaminase 5\/TGM5 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nRabbit Polyclonal Transglutaminase 5\/TGM5 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human TGM5.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human TGM5. The exact immunogen used to generate this antibody is proprietary information.O43548,\u003cbr\u003e\nSpecificity:ab133786 is predicted to not cross-react with other Transglutaminase protein family members. Multiple isoforms of Transglutaminase 5 are known to exist.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTransglutaminase 5 (TGM5) also known as TGase 5 or TG5 is an enzyme part of the transglutaminase family. This enzyme has a molecular mass of about 78 kDa and plays a role in catalyzing the formation of epsilon-(gamma-glutamyl) lysine isopeptide bonds. These covalent bonds contribute to the stability and mechanical properties of proteins. TGM5 is expressed in various tissues with a strong presence in the epidermis indicating its significance in skin cell function and differentiation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTGM5 participates in skin barrier formation and homeostasis. TGM5 acts as a contributor to the crosslinking of structural proteins in the stratum corneum the outermost skin layer. It functions collaboratively integrating with other enzymes within a network that ensures the integrity of the epidermal barrier. This process is essential for skin hydration and resistance against environmental stressors.\u003cbr\u003e\nPathways\u003cbr\u003e\nTGM5 is involved in the keratinocyte differentiation pathway and epidermal barrier repair processes. It works closely alongside proteins such as involucrin and loricrin playing a role in the cornified envelope formation. These proteins and pathways are important for the maintenance of the skin's protective functions and for providing resilience against damage.\u003cbr\u003e\nTGM5 is primarily associated with skin-related conditions such as peeling skin syndrome (PSS) and lamellar ichthyosis. Mutations in the TGM5 gene can disrupt its enzymatic function leading to compromised epidermal barrier integrity. In PSS TGM5 dysfunction can result in abnormal exfoliation of the skin while links between TGM5 and loricrin underline the complexity of keratinization disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854378848425,"sku":"ab133786","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab133786","provider":"Iright","version":"1.0","type":"link"}