{"product_id":"abcam-ab133789","title":"Abcam, ab133789, Anti-Mitochondrial ribosomal protein L11 antibody [EPR9111(B)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Mitochondrial ribosomal protein L11 antibody. Suitable for IHC-P, WB, ICC\/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR9111(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nRat: We have preliminary internal testing data to indicate this antibody may not react with this species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMitochondrial ribosomal protein L11 often called MRPL11 forms an important part of the mitochondrial ribosome or mitoribosome which plays an important role in protein synthesis within the mitochondria. MRPL11 has a mass of approximately 21.3 kDa and is expressed in tissues with high metabolic activity such as the heart and skeletal muscles. It differs from proteins found in the cytosolic ribosomes due to variations in protein to rRNA ratio and the presence of specific mitochondrial sequences.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein contributes to the formation and functional stability of the large subunit of the mitochondrial ribosome. MRPL11 is an integral part of the mitoribosomal complex and it collaborates closely with mitochondrial ribosome protein L10 and L12. The assembly of these proteins ensures efficient mitochondrial translation which subsequently impacts mitochondrial energy production and apoptotic signaling.\u003cbr\u003e\nPathways\u003cbr\u003e\nMRPL11 is deeply embedded in mitochondrial translation and oxidative phosphorylation pathways. These pathways are essential for cellular energy production and metabolism. MRPL11 interacts with other mitochondrial proteins such as mRNA encoders and enzymes in the electron transport chain. It ensures correct assembly and function of the mitochondrial machinery influencing energy demands through the connection to translation regulation and metabolic balance.\u003cbr\u003e\nMRPL11 is associated with mitochondrial disorders like mitochondrial myopathy and neurodegenerative diseases. Mutations or dysregulations in MRPL11 can impair mitochondrial translation leading to compromised energy metabolism. Its dysfunction can involve other mitochondrial proteins such as those forming the electron transport chain or involved in cardiolipin metabolism contributing to the disease mechanisms. Understanding MRPL11's role offers insights into therapeutic targets for disease intervention in these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850391933097,"sku":"ab133789","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab133789","provider":"Iright","version":"1.0","type":"link"}