{"product_id":"abcam-ab134044","title":"Abcam, ab134044, Anti-SLAM \/ CD150 antibody [EPR5470]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal SLAM \/ CD150 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR5470,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSLAM also known as CD150 is a cell surface glycoprotein with a molecular weight of approximately 70 kDa. It is mainly expressed on immune cells such as T cells B cells dendritic cells and macrophages. SLAM\/CD150 serves as a receptor that plays an important role in cellular communication by transmitting signals across the cell membrane. These signals influence various immune responses and cellular functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSLAM\/CD150 acts as a co-stimulatory molecule that augments the activation and proliferation of T and B cells. It participates in forming signaling complexes through interactions with SLAM-associated protein (SAP). As part of these complexes SLAM\/CD150 regulates cytokine production and modulates immune cell interactions and responses. Furthermore SLAM\/CD150 engagement impacts the stability and formation of immunological synapses.\u003cbr\u003e\nPathways\u003cbr\u003e\nSLAM\/CD150 plays a significant role in the immune signaling cascade. It is involved in the SLAM receptor signaling pathway and interacts closely with proteins like SAP and SH2D1A. These interactions enable signal transduction that modulates downstream effects in T and B cell activation within the immune system. SLAM\/CD150's activity affects lymphocyte development and adaptive immune responses.\u003cbr\u003e\nSLAM\/CD150 is connected to autoimmune disorders and infectious diseases. Its altered signaling contributes to disorders such as X-linked lymphoproliferative disease where interactions with the SAP protein are disrupted. Additionally SLAM\/CD150 serves as a receptor for certain viruses including measles virus implicating it in viral pathogenesis and immune evasion mechanisms. Understanding these associations helps elucidate potential therapeutic targets for managing these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850439250089,"sku":"ab134044","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab134044","provider":"Iright","version":"1.0","type":"link"}