{"product_id":"abcam-ab134695","title":"Abcam, ab134695, Anti-AQP0 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal AQP0 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human MIP.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human MIP. The exact immunogen used to generate this antibody is proprietary information.P30301\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAQP0 also known as Aquaporin-0 or MIP (Major Intrinsic Protein) is a water channel protein with a molecular mass of approximately 28 kDa. This protein facilitates the transport of water molecules across cell membranes acting as a critical component in maintaining cellular water homeostasis. AQP0 is expressed primarily in the lens fiber cells of the eye where it plays a significant role in providing transparency and maintaining lens structure.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAQP0 is essential for lens transparency and proper refraction facilitating the alignment and compaction of lens fiber cells. AQP0 acts as both a water channel and a cell-to-cell adhesion molecule in these cells. Through interactions with other proteins in the lens AQP0 contributes to maintaining the lens's unique architecture and mechanical stability although it typically does not form a larger complex on its own.\u003cbr\u003e\nPathways\u003cbr\u003e\nAQP0 plays an important role in the regulation of water balance in the eye lens. The protein functions as an integral part of the water transport pathway in the lens and interacts with other aquaporins such as AQP1 and AQP5. Additionally AQP0 modulates lens permeability affecting pathways tied to lens osmolarity and transparency which are essential for normal vision function.\u003cbr\u003e\nMutations or misregulation of AQP0 are associated with cataracts a condition characterized by the clouding of the lens leading to impaired vision. Disruption in AQP0 functionality can alter lens transparency and homeostasis causing protein aggregation. Research has shown that AQP0 mutations can influence the interactions with other lens proteins like crystallins which are important for lens transparency ultimately leading to cataract development.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854376685737,"sku":"ab134695","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab134695","provider":"Iright","version":"1.0","type":"link"}