{"product_id":"abcam-ab134746","title":"Abcam, ab134746, Anti-LARP7 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal LARP7 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human LARP7 aa 1-50.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human LARP7 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q4G0J3\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab134746 is purified using an epitope specific to LARP7 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nLARP7 also known as La-related protein 7 is a protein with a mass of approximately 63 kDa. It plays an important role in RNA polymerase II-dependent transcription by stabilizing the 7SK snRNP complex. LARP7 is widely expressed in various tissues including the brain liver and kidney. Its expression indicates its involvement in fundamental cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nLARP7 stabilizes the 7SK snRNA which forms part of a multiprotein complex that regulates transcription elongation. This complex controls the activity of positive transcription elongation factor b (P-TEFb) a critical component in managing RNA polymerase II transcription. Through its interaction with the 7SK snRNP complex LARP7 helps regulate gene expression by controlling transcription elongation and maintaining proper cellular function.\u003cbr\u003e\nPathways\u003cbr\u003e\nLARP7 plays a significant role in the regulation of gene expression and transcription elongation pathways. It directly interacts with P-TEFb impacting the control of transcriptional elongation factors. LARP7's function in these pathways highlights its relationship with transcription-related proteins highlighting its integrative role in managing cellular transcription processes.\u003cbr\u003e\nMutations or dysfunctions in LARP7 have associations with certain types of cancer and Alazami syndrome a rare developmental disorder. LARP7's regulatory interaction with P-TEFb and its involvement in transcription elongation implicate it in these conditions. Dysfunctional LARP7 activity can lead to misregulated gene expression contributing to disease pathogenesis and progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853982617769,"sku":"ab134746","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab134746","provider":"Iright","version":"1.0","type":"link"}