{"product_id":"abcam-ab137075","title":"Abcam, ab137075, Anti-NCAPD2 antibody [EPR9220]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal NCAPD2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR9220,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNCAPD2 also known as condensation protein complex subunit 2 is a part of the condensin I complex and is important for chromosome assembly and segregation during mitosis. With an approximate molecular mass of 150 kDa NCAPD2 functions as a regulatory unit within this complex. Researchers find NCAPD2 expression highest in proliferating cells especially in tissues with active cell division such as the bone marrow and some epithelial tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNCAPD2 plays a significant role in maintaining chromosomal architecture during cell division. It is a part of the condensin I complex which is required for the proper condensation and stabilization of chromatids through the cell cycle. NCAPD2 interacts with other proteins within the complex such as SMC2 and SMC4 to ensure efficient DNA packaging and separation aiding in genomic stability.\u003cbr\u003e\nPathways\u003cbr\u003e\nNCAPD2 is heavily involved in the cell cycle control specifically during mitosis. Its role in these pathways ensures the accurate distribution of genetic material to daughter cells. Within the cell cycle pathway NCAPD2 associates with other proteins like topoisomerase II and aurora B kinase which are important for chromosomal segregation and cytokinesis.\u003cbr\u003e\nNCAPD2 dysregulation links to cancer and congenital malformation syndromes. Abnormal function or expression of NCAPD2 might contribute to faulty chromosome condensation leading to genomic instability a hallmark of many cancers. Additionally mutations affecting NCAPD2 and its interaction partners like SMC2 might lead to developmental disorders characterized by structural chromosome anomalies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844204712105,"sku":"ab137075","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab137075","provider":"Iright","version":"1.0","type":"link"}