{"product_id":"abcam-ab1371","title":"Abcam, ab1371, Anti-ATF-4 antibody - C-terminal","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nGoat Polyclonal ATF-4 antibody. C-terminal. Suitable for WB and reacts with Mouse, Pig, Human samples. Cited in 26 publications. Immunogen corresponding to Synthetic Peptide within Human ATF4 aa 300 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Goat,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human, Pig,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ATF4 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P18848,\u003cbr\u003e\nSpecificity:This antibody is expected to recognize both reported isoforms (NP_001666.2; NP_877962.1).\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 0.5% BSA, 0.05% Tris, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nActivating Transcription Factor 4 (ATF-4) also known as CREB-2 is a fundamental protein involved in cellular stress responses. It functions mechanically as a transcription factor that regulates gene expression in reaction to stress signals. The molecular weight of ATF-4 is approximately 38 kDa. ATF-4 gets expressed in various tissues including the brain liver and pancreas reflecting its involvement in diverse cellular processes. Scientists widely use techniques like Western blot to detect and study ATF-4 expression patterns due to its reliable measurement of the ATF-4 molecular weight.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nATF-4 participates in controlling genes linked to amino acid metabolism redox homeostasis and apoptosis. It does not work alone; ATF-4 often forms part of larger complexes interacting with other transcription factors like C\/EBP and ATF-3 to exert its effects. These interactions enable it to respond accurately to different types of cellular stress by adjusting the expression of specific genes ensuring that cells can adapt to changing conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nATF-4 plays a significant role in the integrated stress response (ISR) and the unfolded protein response (UPR). Through these pathways it collaborates with proteins such as PERK (protein kinase R-like endoplasmic reticulum kinase) and eIF2α. The ISR and UPR help cells cope with stress by modulating protein synthesis and promoting the expression of protective genes. By interacting with these pathways ATF-4 contributes to maintaining cellular homeostasis and protecting cells from damage.\u003cbr\u003e\nATF-4 has been linked to conditions such as neurodegenerative diseases and cancer. In neurodegenerative disorders like Alzheimer's disease ATF-4 can regulate genes involved in neuronal survival and apoptosis interacting with proteins like CHOP. In cancer ATF-4 influences tumor cell survival and growth through its role in stress responses. Understanding ATF-4's relationship with diseases highlights its potential as a therapeutic target in the treatment of these complex disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855829881001,"sku":"ab1371","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab1371","provider":"Iright","version":"1.0","type":"link"}