{"product_id":"abcam-ab137989","title":"Abcam, ab137989, Human Protein Z ELISA Kit","description":"\u003cp\u003eSize: 1 x 96Tests\u003cbr\u003e\nHuman Protein Z ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human Protein Z in Human in Biofluids samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nDetection method:Colorimetric,\u003cbr\u003e\nSample types:Plasma, Serum, Milk, Cerebral Spinal Fluid, Urine,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nAssay type:Sandwich (quantitative),\u003cbr\u003e\nSensitivity:\u0026gt; 64 pg\/mL,\u003cbr\u003e\nRange:0.098 - 25 ng\/mL,\u003cbr\u003e\nAssay time:4h,\u003cbr\u003e\nAssay Platform:Microplate\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAbcam's Protein Z Human\u003cbr\u003e\nin vitro\u003cbr\u003e\nELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for the quantitative measurement of Protein Z in plasma, serum, urine, milk, and cell culture supernatants.\u003cbr\u003e\nA Protein Z specific antibody has been precoated onto 96-well plates and blocked. Standards or test samples are added to the wells and subsequently a Protein Z specific biotinylated detection antibody is added and then followed by washing with wash buffer. Streptavidin-Peroxidase Conjugate is added and unbound conjugates are washed away with wash buffer. TMB is then used to visualize Streptavidin-Peroxidase enzymatic reaction. TMB is catalyzed by Streptavidin-Peroxidase to produce a blue color product that changes into yellow after adding acidic stop solution. The density of yellow coloration is directly proportional to the amount of Protein Z captured in plate.\u003cbr\u003e\nThe entire kit may be stored at -20°C for long term storage before reconstitution - Avoid repeated freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions-Multi, Storage information-Please refer to protocols\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nProtein Z also known as PZ is a vitamin K-dependent plasma protein with a molecular mass of approximately 62 kDa. It is primarily expressed in the liver and circulates in the blood. This protein plays a mechanical role in the coagulation system by interacting with the protein Z-dependent protease inhibitor which downregulates blood coagulation contributing to hemostasis. Protein Z is different from other coagulation proteins due to its lack of enzymatic activity but impacts the regulation of thrombin formation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nProtein Z serves as a significant factor in the coagulation cascade being a part of the protein C pathway complex. Although it lacks enzymatic action Protein Z interacts with other proteins such as Factor Xa and Protein Z-dependent protease inhibitor to exert its effects. Its involvement helps modulate clot formation and stabilize the coagulation process impacting blood flow regulation.\u003cbr\u003e\nPathways\u003cbr\u003e\nProtein Z is intricately linked to the coagulation and thrombosis pathways. It associates with proteins including Factor Xa and Protein C. Protein Z assists in regulating thrombin generation by inhibiting excess coagulation maintaining a balance within the hemostatic system. This interaction ensures the rapid and effective stopping of blood flow when required while preventing unwarranted thrombosis a critical aspect of circulatory system maintenance.\u003cbr\u003e\nProtein Z levels link to thrombosis and hemorrhagic disorders. Abnormalities in Protein Z levels have connections with deep vein thrombosis due to its role in regulating coagulation balance. The protein Z-dependent protease inhibitor's association highlights its significance in clot formation and thrombosis prevention. Additionally deficiencies in Protein Z have connections with bleeding disorders emphasizing the protein's role in maintaining a balanced coagulation process essential for preventing excessive bleeding or clotting.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855622787241,"sku":"ab137989","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab137989","provider":"Iright","version":"1.0","type":"link"}