{"product_id":"abcam-ab138487","title":"Abcam, ab138487, Anti-EHM2 antibody [EP6191]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal EHM2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EP6191,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis antibody was developed as part of a collaboration with the lab of Andrei Ivanov at the University of Rochester.\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEHM2 also known as Emp24 domain-containing protein 2 is a mechanistic component of the vesicular trafficking process. Its molecular weight is approximately 27 kDa. This protein is mainly expressed in tissues such as the liver and heart. EHM2 plays a role in the transport of cargo molecules from the endoplasmic reticulum to the Golgi apparatus assisting in cellular organization and protein sorting.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEHM2 functions as a part of the p24 protein complex which is essential for the vesicular transport system. This complex helps maintain the integrity and fidelity of transport vesicles. EHM2 interacts with the COPII and COPI coat protein complexes ensuring proper cargo selection and vesicle budding. It aids in maintaining cellular homeostasis through its contribution to efficient intracellular transport mechanisms.\u003cbr\u003e\nPathways\u003cbr\u003e\nEHM2 participates in intracellular protein transport and secretion pathways. It plays a role in the ER-Golgi transport pathway and interacts with proteins like Sec24 and COPI integral components for vesicle formation and budding from the ER. These interactions facilitate the accurate transport of protein cargo and are necessary for maintaining protein distribution throughout the cell.\u003cbr\u003e\nEHM2 shows connection to metabolic and cardiovascular diseases. Due to its expression in the liver and heart imbalances in EHM2 function may contribute to disorders such as fatty liver disease and cardiomyopathy. EHM2 interacts with proteins like apolipoproteins in these conditions potentially influencing lipid metabolism and cardiovascular health. Understanding EHM2's role could offer insights into therapeutic interventions for these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850228813993,"sku":"ab138487","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab138487","provider":"Iright","version":"1.0","type":"link"}