{"product_id":"abcam-ab139190","title":"Abcam, ab139190, Anti-LZP antibody [EPR9348]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal LZP antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR9348,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nRat: We have preliminary internal testing data to indicate this antibody may not react with this species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nLZP also known as leucine zipper protein is a structural protein that plays a significant role in various cellular processes. It has a molecular mass of approximately 25 kDa. LZP is expressed highly in the liver and lungs with moderate expression observed in the brain and heart. The presence of the leucine zipper motif in LZP allows it to function as a transcription factor facilitating the regulation of gene expression through dimerization and DNA binding.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nLZP interacts with other proteins to regulate cell proliferation and differentiation. The protein forms part of a larger complex involved in these cellular processes. Through its action in transcription regulation LZP influences the expression of genes critical for cell cycle progression and apoptosis. During normal cellular function LZP maintains a balance between cell growth and programmed cell death contributing to tissue homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearch identifies LZP playing a role in the MAPK\/ERK signaling pathway and the NF-κB signaling pathway. These pathways are essential for transmitting signals from the cell surface to the DNA in the nucleus impacting cell survival and differentiation. LZP interacts closely with proteins such as c-Jun and p53 within these pathways suggesting its importance in signal transduction and gene transcription.\u003cbr\u003e\nLZP has connections to certain types of cancer including liver and lung cancer. Studies indicate that aberrant expression or mutations in LZP can lead to uncontrolled cell proliferation contributing to tumorigenesis. In addition LZP's interaction with the protein p53 known for its tumor-suppressing activities highlights its role in these diseases. Understanding LZP's functions and pathways offers potential targets for therapeutic intervention in related disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850223767721,"sku":"ab139190","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab139190","provider":"Iright","version":"1.0","type":"link"}