{"product_id":"abcam-ab141028","title":"Abcam, ab141028, Dextromethorphan hydrobromide, NMDA receptor antagonist","description":"\u003cp\u003eSize: 50mg\u003cbr\u003e\nMW 370.3 Da, Purity \u0026gt;99%. Non-competitive, low affinity NMDA receptor antagonist. Displays antitussive and neuroprotective effects. Active  in vivo . Also available in simple stock solutions (ab146729) - add 1 ml of water to get an exact, ready-to-use concentration.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:6700-34-1,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:370.3 Da,\u003cbr\u003e\nMolecular formula:C18H28BrNO2,\u003cbr\u003e\nPubChem:5462351,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in water to 50 mMSoluble in ethanol to 100 mM,\u003cbr\u003e\nBiochemical name:Dextromethorphan hydrobromide,\u003cbr\u003e\nBiological description:Non-competitive, low affinity NMDA receptor antagonist. Displays antitussive and neuroprotective effects. Active in vivo.Also available in simple stock solutions (ab146729) - add 1 ml of water to get an exact, ready-to-use concentration.,\u003cbr\u003e\nCanonical smiles:CN1CCC23CCCCC2C1CC4=C3C=C(C=C4)OC.O.Br,\u003cbr\u003e\nIsomeric smiles:CN1CC[C@@]23CCCC[C@@H]2[C@@H]1CC4=C3C=C(C=C4)OC.O.Br,\u003cbr\u003e\nInChi:InChI=1S\/C18H25NO.BrH.H2O\/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18;;\/h6-7,12,15,17H,3-5,8-11H2,1-2H3;1H;1H2\/t15-,17+,18+;;\/m1..\/s1,\u003cbr\u003e\nInChiKey:STTADZBLEUMJRG-IKNOHUQMSA-N,\u003cbr\u003e\nIUPAC Name:(1S,9S,10S)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene;hydrate;hydrobromide\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGlutamate Receptor 1 also known as AMPA receptor GluA1 or GRIA1 is an important component of the fast excitatory synaptic transmission in the central nervous system. This receptor subunit weighs approximately 100 kDa and is found in high concentration in the brain particularly in areas like the hippocampus and cortex. Functionally GRIA1 facilitates synaptic plasticity and the transmission of excitatory signals by controlling calcium permeability through AMPA receptor channels.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe Glutamate Receptor 1 plays a significant role as part of the ionotropic glutamate receptor complex. It interacts with other subunits such as GluA2 to form homomeric or heteromeric assemblies that determine the receptor's permeability and kinetics. The activation of these receptor complexes influences learning and memory processes through long-term potentiation (LTP) and long-term depression (LTD) in neurons.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe Glutamate Receptor 1 is integral to the glutamatergic signaling pathway which is essential for neuronal communication. This pathway involves the activation of AMPA receptors which work in concert with NMDA receptors to modulate synaptic strength. GRIA1 also associates with proteins like Stargazin an auxiliary subunit that influences receptor localization and trafficking playing a vital role in synaptic function and plasticity.\u003cbr\u003e\nThe malfunction of the Glutamate Receptor 1 has associations with neurological conditions such as epilepsy and schizophrenia. Alterations in GRIA1 expression or function can contribute to the synaptic anomalies observed in these disorders. Similarly GRIA1's interaction with other proteins like SynGAP implicated in the regulation of synaptic signaling highlights its involvement in neurodevelopmental and psychiatric conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847454118057,"sku":"ab141028","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab141028","provider":"Iright","version":"1.0","type":"link"}