{"product_id":"abcam-ab141043","title":"Abcam, ab141043, Tropicamide, M4 antagonist","description":"\u003cp\u003eSize: 100mg\u003cbr\u003e\nMW 284.35 Da, Purity \u0026gt;98%. Potent, selective M4 antagonist (pKi = 7.85). Achieve your results faster with highly validated, pure and trusted compounds.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1508-75-4,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:284.35 Da,\u003cbr\u003e\nMolecular formula:C17H20N2O2,\u003cbr\u003e\nPubChem:5593,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mMSoluble in ethanol to 20 mM,\u003cbr\u003e\nBiochemical name:Tropicamide,\u003cbr\u003e\nBiological description:Potent, selective M4 antagonist (pKi = 7.85).,\u003cbr\u003e\nCanonical smiles:CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2,\u003cbr\u003e\nInChi:InChI=1S\/C17H20N2O2\/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15\/h3-11,16,20H,2,12-13H2,1H3,\u003cbr\u003e\nInChiKey:BGDKAVGWHJFAGW-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMuscarinic acetylcholine receptors specifically CHRM1 CHRM3 CHRM4 and CHRM5 are part of the G protein-coupled receptor family. These receptors also known by names such as M1-M5 receptors play critical roles in mediating cholinergic neurotransmission. Molecular weights vary among these receptors but they generally range around 70 kDa. These receptors are highly expressed in central nervous system regions such as cerebral cortex hippocampus and striatum as well as some peripheral tissues. Aromatase another biological target functions as an enzyme that converts androgens to estrogens and is expressed in various tissues including the brain and gonads.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMuscarinic receptors affect numerous processes by regulating neurotransmitter release and they are integral to modulating synaptic plasticity memory and learning. They do not form part of a complex but interact with various signaling molecules. Aromatase's biological role involves steroid hormone conversion important for maintaining hormonal balances. Its activity leads to estrogen production impacting reproductive and non-reproductive tissues importantly in the maintenance of physiological homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nThese receptors participate prominently in cholinergic pathways that influence cognitive and autonomic functions. They interact with signaling proteins like G-proteins and second messengers which mediate neurotransmission and physiological responses. Aromatase fits primarily into steroidogenesis pathways working alongside steroidogenic enzymes to modulate hormone profiles and impact various metabolic and cellular activities.\u003cbr\u003e\nMuscarinic receptors are implicated in neurological conditions such as Alzheimer’s disease and schizophrenia. Deregulation of these receptors connects to imbalances in neurotransmission and cognitive functions. Aromatase is associated with hormone-dependent cancers like breast cancer given its role in estrogen production. Its activity links to estrogen receptors highlighting its influence on estrogen-responsive tissues in cancer progression and therapy outcomes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847472074921,"sku":"ab141043","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab141043","provider":"Iright","version":"1.0","type":"link"}