{"product_id":"abcam-ab141046","title":"Abcam, ab141046, Imipramine hydrochloride, Tricyclic antidepressant","description":"\u003cp\u003eSize: 5g\u003cbr\u003e\nMW 316.9 Da, Purity \u0026gt;98%. Tricyclic antidepressant with various pharmacological activities. Inhibits reuptake inhibitors (K i  values are 19, 98 and \u0026gt;1000 nM for SERT, NET and DAT, respectively). Muscarinic receptor inhibitor (IC 50  = 0.13 μM for M 2 ). Serotonin receptor inhibitor (K i  values are 94 and 160 nM for 5-HT 2A  and 5-HT 2C , respectively). Crosses the blood-brain barrier.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:113-52-0,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:316.9 Da,\u003cbr\u003e\nMolecular formula:C19H25ClN2,\u003cbr\u003e\nPubChem:8228,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in water to 100 mM,\u003cbr\u003e\nBiochemical name:Imipramine hydrochloride,\u003cbr\u003e\nBiological description:Tricyclic antidepressant with various pharmacological activities. Inhibits reuptake inhibitors (Ki values are 19, 98 and \u0026gt;1000 nM for SERT, NET and DAT, respectively). Muscarinic receptor inhibitor (IC50 = 0.13 μM for M2). Serotonin receptor inhibitor (Ki values are 94 and 160 nM for 5-HT2A and 5-HT2C, respectively). Crosses the blood-brain barrier.,\u003cbr\u003e\nCanonical smiles:CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31.Cl,\u003cbr\u003e\nInChi:InChI=1S\/C19H24N2.ClH\/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;\/h3-6,8-11H,7,12-15H2,1-2H3;1H,\u003cbr\u003e\nInChiKey:XZZXIYZZBJDEEP-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine;hydrochloride\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe c-Jun protein also known as a component of the activator protein 1 (AP-1) transcription factor interacts with various cellular mechanisms. It is expressed in many different cell types including neuronal and immune cells. c-Jun plays a pivotal role in regulating gene expression apoptosis and cell proliferation. The protein has a mass of approximately 39 kDa and forms heterodimers with proteins like c-Fos. Other proteins of interest on the list include the Androgen Receptor and Retinoic Acid Receptor alpha both nuclear receptors involved in hormone signaling. The Maxi Potassium channel alpha\/SLO and Maxi Potassium channel beta\/KCNMB1 modulate potassium ion flow across cell membranes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese targets influence critical cellular functions such as signal transduction and transcriptional regulation. c-Jun as part of the AP-1 complex mediates responses to various stress signals while the Androgen Receptor regulates gene expression related to male sexual development. Retinoic Acid Receptor alpha partners with Retinoid X Receptor alpha to form heterodimers that control differentiation and apoptosis. The PXR or Pregnane X Receptor is involved in xenobiotic metabolism. Potassium channels like KCNMB1 and KCNMB4 adjust membrane potential and cellular excitability.\u003cbr\u003e\nPathways\u003cbr\u003e\nSeveral proteins like c-Jun and the Androgen Receptor are integral to signaling cascades such as the MAPK\/ERK and androgen signaling pathways respectively. These pathways are important for processes like cell growth and differentiation. Retinoic Acid Receptor alpha and RXRA influence the retinoic acid signaling pathway which is critical for cell differentiation. Proteins such as the Serotonin transporter also interface with neuronal signaling pathways impacting mood regulation.\u003cbr\u003e\nC-Jun is associated with cancer and inflammatory diseases due to its role in cell proliferation and response to stress. Androgen Receptor mutations or dysregulation can lead to prostate cancer and androgen insensitivity syndrome. Dysfunctions in the Maxi Potassium channel can result in cardiovascular diseases like hypertension. Meanwhile the Serotonin transporter targeted by drugs like imipramine hydrochloride plays a significant role in depression and anxiety disorders connecting it to the action of antidepressants.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847431344297,"sku":"ab141046","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab141046","provider":"Iright","version":"1.0","type":"link"}