{"product_id":"abcam-ab141063","title":"Abcam, ab141063, Taurine, Partial glycine receptor agonist","description":"\u003cp\u003eSize: 1g\u003cbr\u003e\nMW 125.15 Da, Purity \u0026gt;98%. Partial glycine receptor agonist. Abundant free amino acid in the retina and central brain and elicits a variety of biological effects. Able to cross the blood-brain barrier.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:107-35-7,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:125.15 Da,\u003cbr\u003e\nMolecular formula:NH2CH2CH2SO3H,\u003cbr\u003e\nPubChem:1123,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in water to 100 mM,\u003cbr\u003e\nBiochemical name:Taurine,\u003cbr\u003e\nBiological description:Partial glycine receptor agonist. Abundant free amino acid in the retina and central brain and elicits a variety of biological effects. Able to cross the blood-brain barrier.,\u003cbr\u003e\nCanonical smiles:C(CS(=O)(=O)O)N,\u003cbr\u003e\nInChi:InChI=1S\/C2H7NO3S\/c3-1-2-7(4,5)6\/h1-3H2,(H,4,5,6),\u003cbr\u003e\nInChiKey:XOAAWQZATWQOTB-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:2-aminoethanesulfonic acid\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe c-Jun protein also known as Jun oncogene is a component of the AP-1 transcription factor complex. It has an approximate mass of 39 kDa and is expressed in various tissues across the human body. Aryl hydrocarbon Receptor (AhR) with a mass of around 96 kDa acts as a ligand-activated transcription factor and is also widely expressed especially in the liver. Retinoic Acid Receptor alpha (RARα) weighing about 50 kDa mediates gene expression changes in response to retinoic acid. It mainly appears in tissues with high cell turnover. Estrogen Related Receptor alpha (ERRα) shares structural features with steroid hormone receptors and is notably present in reproductive tissues and metabolic organs. Nrf2 also known as nuclear factor erythroid 2–related factor 2 has approximately 68 kDa in mass and plays a role in regulating oxidative response genes. It expresses broadly particularly in organs facing high oxidative stress.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nC-Jun activates as part of a transcription factor complex such as AP-1 impacting cellular proliferation and differentiation. Aryl hydrocarbon Receptor allows cells to respond to environmental toxins and is part of a complex involving co-chaperones such as Hsp90. Retinoic Acid Receptor alpha modulates gene expression during embryonic development and is part of heterodimer complexes with RXR. Estrogen Related Receptor alpha (ERRα) influences energy metabolism and regulates mitochondrial biogenesis. Nrf2 upregulates antioxidant proteins to maintain redox homeostasis forming a complex with Keap1 in its inactive or repressed state.\u003cbr\u003e\nPathways\u003cbr\u003e\nC-Jun integrates into signaling cascades such as the MAPK and JNK pathways affecting genes related to stress response and apoptosis. The Aryl hydrocarbon Receptor participates in xenobiotic metabolism pathways interacting with proteins like CYP1A1. Retinoic Acid Receptor alpha influences developmental signaling pathways like the Wnt pathway sharing regulation roles with proteins such as beta-catenin. ERRα is involved in energy metabolism pathways intersecting with the PGC-1α family critical for mitochondrial biogenesis. Nrf2 plays an important role in the antioxidant response element (ARE) pathway interacting with proteins like small Maf.\u003cbr\u003e\nC-Jun is associated with cancer progression and inflammatory diseases interacting with other proteins involved in these conditions like NF-kB. AhR dysfunction links to immune disorders and liver diseases with pathways that share involvement with CYP450 enzymes. Abnormal Retinoic Acid Receptor alpha function is implicated in acute promyelocytic leukemia and developmental disorders interacting with partners such as the fusion protein PML-RARα. Dysregulated ERRα touches on metabolic disorders and cancer with related proteins like PPARγ influencing disease. Nrf2's impaired activity connects to neurodegenerative diseases and chronic obstructive pulmonary disease (COPD) with its pathway involving Keap1.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847472107689,"sku":"ab141063","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab141063","provider":"Iright","version":"1.0","type":"link"}