{"product_id":"abcam-ab141130","title":"Abcam, ab141130, Idazoxan hydrochloride, alpha2 Adrenoceptor antagonist and I2 ligand","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 240.68 Da, Purity \u0026gt;99%. α2 Adrenoceptor antagonist and I2 ligand. Improves motor symptoms and decreases dyskinesia in Parkinson's disease models. Also induces apoptosis. Active *in vivo*.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:79944-56-2,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:240.68 Da,\u003cbr\u003e\nMolecular formula:C11H13ClN2O2,\u003cbr\u003e\nPubChem:154494,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in water to 100 mM,\u003cbr\u003e\nBiochemical name:Idazoxan hydrochloride,\u003cbr\u003e\nBiological description:α2 Adrenoceptor antagonist and I2 ligand. Improves motor symptoms and decreases dyskinesia in Parkinson's disease models. Also induces apoptosis. Active *in vivo*.,\u003cbr\u003e\nCanonical smiles:C1CN=C(N1)C2COC3=CC=CC=C3O2.Cl,\u003cbr\u003e\nInChi:InChI=1S\/C11H12N2O2.ClH\/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11;\/h1-4,10H,5-7H2,(H,12,13);1H,\u003cbr\u003e\nInChiKey:MYUBYOVCLMEAOH-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:2-(2,3-dihydro-1,4-benzodioxin-3-yl)-4,5-dihydro-1H-imidazole;hydrochloride\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe alpha-2 adrenergic receptors including receptor subtypes like ADRA2B ADRA2C and alpha-2A function as G protein-coupled receptors that inhibit the release of norepinephrine and other neurotransmitters in the central and peripheral nervous system. These receptors have a mass close to 50 kDa and express in various tissues including the brain spinal cord and vascular smooth muscles. Additionally Idazoxan acts as an antagonist ligand for these receptors. Another key protein TDP1 is known for its role in DNA repair processes while Geminin is involved in regulating DNA replication. Moreover Estrogen Related Receptor alpha (ERRα) is a nuclear receptor that influences metabolic processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAlpha-adrenergic receptors including the ADRA2B and ADRA2C modulate neurochemical release and vascular tone contributing to responses such as vasoconstriction and lowering of blood pressure. Not functioning alone these receptors can be part of larger receptor complexes that coordinate multiple signal cascades. TDP1 plays a significant role in maintaining DNA integrity collaborating with other DNA repair proteins. Geminin on the other hand ensures proper DNA replication without over-replication. ERRα regulates energy homeostasis and lipid metabolism through its influence on gene transcription-related pathways.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe alpha-2 adrenergic receptors participate significantly in adrenergic signaling impacting cellular responses to stress and metabolic function. They involve proteins such as G-proteins and other neurotransmitter-related proteins. Meanwhile TDP1 is essential in the DNA repair pathway associated with phosphodiester bonds and is linked to proteins engaged in coordinating DNA damage responses. ERRα operates within metabolic pathways particularly influencing pathways related to mitochondrial biogenesis and oxidative phosphorylation alongside key metabolic enzymes.\u003cbr\u003e\nDysregulation of alpha-2 adrenergic receptors links to hypertension and stress-related conditions as they impact cardiovascular and nervous system functions. Their altered function might also engage different adrenergic receptor subtypes impacting other physiological responses. TDP1 mutations can associate with neurodegenerative disorders like Huntington's disease implicating proteins involved in DNA repair cascades. Meanwhile ERRα has been connected with metabolic diseases such as diabetes linking it to disorders through altered metabolic protein interactions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847475515561,"sku":"ab141130","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab141130","provider":"Iright","version":"1.0","type":"link"}