{"product_id":"abcam-ab141203","title":"Abcam, ab141203, Dapsone, Antibacterial and anti-inflammatory agent","description":"\u003cp\u003eSize: 250mg\u003cbr\u003e\nMW 248.3 Da, Purity \u0026gt;99%. Antibacterial and anti-inflammatory agent. Neuroprotective and anti-apoptotic effects.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:80-08-0,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:248.3 Da,\u003cbr\u003e\nMolecular formula:C12H12N2O2S,\u003cbr\u003e\nPubChem:2955,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mMSoluble in ethanol to 25 mM,\u003cbr\u003e\nBiochemical name:Dapsone,\u003cbr\u003e\nBiological description:Antibacterial and anti-inflammatory agent. Neuroprotective and anti-apoptotic effects.,\u003cbr\u003e\nCanonical smiles:C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N,\u003cbr\u003e\nInChi:InChI=1S\/C12H12N2O2S\/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12\/h1-8H,13-14H2,\u003cbr\u003e\nInChiKey:MQJKPEGWNLWLTK-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:4-(4-aminophenyl)sulfonylaniline\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions|The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe 5HT6 receptor also known as 5-hydroxytryptamine receptor 6 is a protein with a molecular mass of approximately 45 kDa. It is a G protein-coupled receptor (GPCR) that primarily binds serotonin and is expressed in the brain mainly in regions like the striatum olfactory tubercle and hippocampus. The receptor's mechanical role involves modulating neurotransmitter release and neuronal excitability which influences cognitive processes such as learning and memory.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe 5HT6 receptor plays an integral role in modulating serotonergic transmission in the central nervous system. While it does not form a complex with other proteins its activity influences several neurotransmitter systems including dopamine and glutamate. By regulating these systems the receptor supports cognitive functions and affects mood regulation highlighting its significance in neuropsychological processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe 5HT6 receptor holds a role in the serotonergic neurotransmission pathway and the receptor-mediated phosphoinositide pathway. It interacts with key proteins such as the adenylyl cyclase influencing cAMP accumulation and downstream signaling processes that impact synaptic plasticity and neurodevelopment. Its interaction with other receptors such as dopamine D2 receptors further defines its involvement in complex neuromodulatory networks.\u003cbr\u003e\nThe 5HT6 receptor links to neurological and psychiatric conditions like Alzheimer's disease and schizophrenia. Dysregulation of 5HT6 activity is associated with cognitive deficits and an altered mood where it also interacts with amyloid precursor protein (APP) and histamine H3 receptors respectively. Therapeutics targeting 5HT6 are under investigation for their potential to alleviate symptoms or modify disease progression in these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847452938409,"sku":"ab141203","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab141203","provider":"Iright","version":"1.0","type":"link"}