{"product_id":"abcam-ab141312","title":"Abcam, ab141312, Nomega-Nitro-L-arginine (L-NNA), Nitric oxide synthase inhibitor","description":"\u003cp\u003eSize: 100mg\u003cbr\u003e\nMW 219.2 Da, Purity \u0026gt;99%. Nitric oxide synthase inhibitor (K i  = 4.4 μM). Cardiovascular effects. Active  in vivo .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:2149-70-4,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:219.2 Da,\u003cbr\u003e\nMolecular formula:C6H13N5O4,\u003cbr\u003e\nPubChem:440005,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in water to 5 mM,\u003cbr\u003e\nBiochemical name:Nitroarginine,\u003cbr\u003e\nBiological description:Nitric oxide synthase inhibitor (Ki = 4.4 μM). Cardiovascular effects. Active in vivo.,\u003cbr\u003e\nCanonical smiles:C(CC(C(=O)O)N)CN=C(N)N[N+](=O)[O-],\u003cbr\u003e\nIsomeric smiles:C(C[C@@H](C(=O)O)N)CN=C(N)N[N+](=O)[O-],\u003cbr\u003e\nInChi:InChI=1S\/C6H13N5O4\/c7-4(5(12)13)2-1-3-9-6(8)10-11(14)15\/h4H,1-3,7H2,(H,12,13)(H3,8,9,10)\/t4-\/m0\/s1,\u003cbr\u003e\nInChiKey:MRAUNPAHJZDYCK-BYPYZUCNSA-N,\u003cbr\u003e\nIUPAC Name:(2S)-2-amino-5-[[amino(nitramido)methylidene]amino]pentanoic acid\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEndothelial nitric oxide synthase (eNOS) inducible nitric oxide synthase (iNOS) and the Prostaglandin E Receptor EP2 (PTGER2) represent a diverse group of proteins with significant roles in various physiological processes. eNOS also known under the names NOS3 is primarily localized in endothelial cells and weighs approximately 133 kDa. It catalyzes the production of nitric oxide (NO) from L-arginine. Meanwhile iNOS is expressed in macrophages and some vascular cells and plays a role in immune responses. PTGER2 on the other hand is a receptor for prostaglandin E2 expressed in numerous tissues including the brain and kidneys. Each entity has a distinct function but shares interrelated pathways.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese proteins and receptors influence various cellular functions and behavior. eNOS produces NO which acts as a signaling molecule facilitating vasodilation and influencing vascular tone. iNOS becomes activated during inflammatory responses and contributes to immune defense by producing NO. PTGER2 a G-protein-coupled receptor mediates the actions of prostaglandin E2 influencing processes like inflammation and vasodilation. While these proteins and receptors do not form a single complex they function collaboratively or independently within the cellular environment.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe roles played by eNOS iNOS and PTGER2 integrate into broader biological networks. eNOS and iNOS are integral parts of the nitric oxide signaling pathway where NO interacts with guanylate cyclase to influence vascular smooth muscle relaxation. PTGER2 connects to the prostaglandin signaling pathway regulating complex physiological responses. These pathways often intersect sharing links with proteins such as cyclooxygenase-2 (COX-2) and guanylate cyclase important in modulating inflammation and vascular homeostasis.\u003cbr\u003e\nThe functions of eNOS iNOS and PTGER2 contribute to various pathological conditions. Dysfunction of eNOS often related to reduced NO availability associates with cardiovascular disorders including hypertension and atherosclerosis. Dysregulation of iNOS expression links to chronic inflammatory states such as rheumatoid arthritis. PTGER2's role in inflammation and vascular regulation connects it to disorders including inflammatory bowel disease interacting with proteins like COX-2 potentiating chronic inflammation. These interactions highlight both potential therapeutic targets and areas for further research.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847422398633,"sku":"ab141312","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab141312","provider":"Iright","version":"1.0","type":"link"}