{"product_id":"abcam-ab141407","title":"Abcam, ab141407, BIX 01294, histone methyltransferase inhibitor","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 490.6 Da, Purity \u0026gt;95%. Potent, selective G9a and G9a-like protein histone lysine methyltransferase inhibitor (IC 50  values are 1.7 and 0.7 μM at G9a and G9a-like protein, respectively). No activity at other HMT up to 37 μM. Antimalarial agent. Active  in vitro .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:935693-62-2,\u003cbr\u003e\nPurity:\u0026gt;95%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:490.6 Da,\u003cbr\u003e\nMolecular formula:C28H38N6O2,\u003cbr\u003e\nPubChem:25150857,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nBiochemical name:N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine,\u003cbr\u003e\nBiological description:Potent, selective G9a and G9a-like protein histone lysine methyltransferase inhibitor (IC50 values are 1.7 and 0.7 μM at G9a and G9a-like protein, respectively). No activity at other HMT up to 37 μM. Antimalarial agent. Active in vitro.,\u003cbr\u003e\nCanonical smiles:CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC,\u003cbr\u003e\nInChi:InChI=1S\/C28H38N6O2\/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21\/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31),\u003cbr\u003e\nInChiKey:OSXFATOLZGZLSK-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 1678 BIX 01294. 1678-25 is the same size as the 25 mg size of ab141407.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEHMT1 also known as GLP (G9a-like protein) is a histone methyltransferase involved in the methylation of histone H3 on lysine 9 a modification leading to transcriptional repression. The EHMT1 protein has a mass of approximately 150 kDa and is expressed in numerous tissues including the brain and heart. It functions as part of a larger complex and acts in the modification of chromatin structure and gene expression regulation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEHMT1\/GLP plays a critical role in cellular processes such as development and differentiation. It forms a complex with G9a another histone methyltransferase to facilitate these functions. This complex cooperates in controlling gene silencing and the preservation of cellular identity. Such complex mechanisms lead to alterations in gene expression patterns that are essential for normal cellular operation.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe methylation activity of EHMT1\/GLP participates in the epigenetic regulation pathway and chromatin remodeling pathways. Within these pathways it interacts closely with proteins like HP1 which binds to methylated histones to promote gene silencing. The connections with pathways that influence gene expression affirm its role in maintaining cellular processes like proliferation and embryonic development.\u003cbr\u003e\nResearchers connect EHMT1\/GLP to Kleefstra syndrome—a condition characterized by intellectual disability and developmental delays. It is also associated with some cancer types due to its epigenetic regulation influences. In these contexts abnormal EHMT1\/GLP activity often involving other proteins like G9a can contribute to the disruptions in gene regulation that lead to disease manifestations.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847430230185,"sku":"ab141407","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab141407","provider":"Iright","version":"1.0","type":"link"}