{"product_id":"abcam-ab141447","title":"Abcam, ab141447, SU 1498, VEGFR2 inhibitor","description":"\u003cp\u003eSize: 1mg \/ 5mg\u003cbr\u003e\nMW 390.5 Da, Purity \u0026gt;99%. Selective VEGFR-2 inhibitor (IC 50  = 700 nM). Shows antiangiogenic activity. Active  in vivo .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:168835-82-3,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:390.5 Da,\u003cbr\u003e\nMolecular formula:C25H30N2O2,\u003cbr\u003e\nPubChem:5941539,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in ethanol to 100 mMSoluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:(E)-2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide,\u003cbr\u003e\nBiological description:Selective VEGFR-2 inhibitor (IC50 = 700 nM). Shows antiangiogenic activity. Active in vivo.,\u003cbr\u003e\nCanonical smiles:CC(C)C1=CC(=CC(=C1O)C(C)C)C=C(C#N)C(=O)NCCCC2=CC=CC=C2,\u003cbr\u003e\nIsomeric smiles:CC(C)C1=CC(=CC(=C1O)C(C)C)\/C=C(\\C#N)\/C(=O)NCCCC2=CC=CC=C2,\u003cbr\u003e\nInChi:InChI=1S\/C25H30N2O2\/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19\/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)\/b21-13+,\u003cbr\u003e\nInChiKey:JANPYFTYAGTSIN-FYJGNVAPSA-N,\u003cbr\u003e\nIUPAC Name:(E)-2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]-N-(3-phenylpropyl)prop-2-enamide\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nIt is important to note that this product has been reported to be unstable under a variety of conditions. In addition to being unstable to light and air after extended periods of time, this product is extremely unstable in polar solvents such as DMSO. Within 1 hour a DMSO solution showed signs of decomposition. We therefore recommend this material is only stored as the solid form at -20°C (or below), with the exclusion of light and air, and any solutions are made up fresh and used immediately\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, Store under desiccating conditions, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nVEGF Receptor 2 also known as KDR or FLK-1 is a receptor tyrosine kinase with a mass of approximately 200 kDa. This receptor is mainly expressed on endothelial cells and is found in multiple body tissues where angiogenesis occurs such as the lungs and kidneys. VEGF Receptor 2 is responsible for binding to vascular endothelial growth factor (VEGF) which initiates a signaling cascade that promotes cell survival migration and new blood vessel formation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nVEGF Receptor 2 plays an important role in angiogenesis and is essential for vascular development during both physiological and pathological processes. Through interactions with VEGF-A VEGF Receptor 2 forms a signaling complex that activates downstream pathways involved in cellular proliferation and differentiation. This receptor ensures a supply of nutrients and oxygen by facilitating the development of blood vessels in response to hypoxic conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe intracellular signaling initiated by VEGF Receptor 2 involves pathways like the PI3K\/Akt pathway and the MAPK\/ERK pathway. These pathways are critical for mediating cell survival growth and division. VEGF Receptor 2 is also closely related to VEGF Receptor 1 another member of the same receptor family which can modulate the receptor's activity by acting as a decoy receptor therefore affecting angiogenic responses.\u003cbr\u003e\nVEGF Receptor 2 has a significant role in cancer and age-related macular degeneration. In many tumors elevated VEGF levels lead to increased activity of VEGF Receptor 2 which results in abnormal blood vessel growth and tumor expansion. The receptor is also implicated in pathological angiogenesis associated with age-related macular degeneration as it promotes neovascularization that can lead to vision loss. Targeting VEGF Receptor 2 for therapeutic interventions often involves VEGF inhibitors which reduce its activity and slow disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847427379369,"sku":"ab141447","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab141447","provider":"Iright","version":"1.0","type":"link"}