{"product_id":"abcam-ab141462","title":"Abcam, ab141462, SR1001, RORalpha and RORgammat inverse agonist","description":"\u003cp\u003eSize: 5mg\u003cbr\u003e\nMW 477.4 Da, Purity \u0026gt;98%. Potent, selective RORα and RORγt inverse agonist (K i  values are 172 and 111 nM for RORα and RORγ respectively). Suppresses IL-17 promoter driven transcriptional activity. Inhibits TRAP220 nuclear receptor box 2 peptide interaction (IC 50  = 117 nM). Shows immunosuppressant effects  in vivo. .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1335106-03-0,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:477.4 Da,\u003cbr\u003e\nMolecular formula:C15H13F6N3O4S2,\u003cbr\u003e\nPubChem:44241473,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 10 mM,\u003cbr\u003e\nBiochemical name:N-[5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]sulfamoyl]-4-methyl-1,3-thiazol-2-yl]acetamide,\u003cbr\u003e\nBiological description:Potent, selective RORα and RORγt inverse agonist (Ki values are 172 and 111 nM for RORα and RORγ respectively). Suppresses IL-17 promoter driven transcriptional activity. Inhibits TRAP220 nuclear receptor box 2 peptide interaction (IC50 = 117 nM). Shows immunosuppressant effects in vivo.,\u003cbr\u003e\nCanonical smiles:CC1=C(SC(=N1)NC(=O)C)S(=O)(=O)NC2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O,\u003cbr\u003e\nInChi:InChI=1S\/C15H13F6N3O4S2\/c1-7-11(29-12(22-7)23-8(2)25)30(27,28)24-10-5-3-9(4-6-10)13(26,14(16,17)18)15(19,20)21\/h3-6,24,26H,1-2H3,(H,22,23,25),\u003cbr\u003e\nInChiKey:OZBSSKGBKHOLGA-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:N-[5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]sulfamoyl]-4-methyl-1,3-thiazol-2-yl]acetamide\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 1902 SR1001. 1902-25 is the same size as the 25 mg size of ab141462.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847449202857,"sku":"ab141462","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab141462","provider":"Iright","version":"1.0","type":"link"}