{"product_id":"abcam-ab141579","title":"Abcam, ab141579, SB-3CT, MMP-2 and MMP-9 inhibitor","description":"\u003cp\u003eSize: 1mg \/ 5mg\u003cbr\u003e\nMW 306.4 Da, Purity \u0026gt;98%. Potent, competitive and non-selective MMP-2 and MMP-9 inhibitor (K i  values are 13.9 and 600 nM for MMP-2 and MMP-9 respectively). Does not alter the activity of MMP-1, MMP-3 or MMP-7 (K i  values are 206 (MMP-1), 15 (MMP-3) and 96 (MMP-7) μM). Neuroprotective and blood-brain barrier permeable.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:292605-14-2,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:306.4 Da,\u003cbr\u003e\nMolecular formula:C15H14O3S2,\u003cbr\u003e\nPubChem:9883002,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 25 mMSoluble in ethanol,\u003cbr\u003e\nBiochemical name:2-[(4-Phenoxyphenyl)sulfonylmethyl]thiirane,\u003cbr\u003e\nBiological description:Potent, competitive and non-selective MMP-2 and MMP-9 inhibitor (Ki values are 13.9 and 600 nM for MMP-2 and MMP-9 respectively). Does not alter the activity of MMP-1, MMP-3 or MMP-7 (Ki values are 206 (MMP-1), 15 (MMP-3) and 96 (MMP-7) μM). Neuroprotective and blood-brain barrier permeable.,\u003cbr\u003e\nCanonical smiles:C1C(S1)CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3,\u003cbr\u003e\nInChi:InChI=1S\/C15H14O3S2\/c16-20(17,11-14-10-19-14)15-8-6-13(7-9-15)18-12-4-2-1-3-5-12\/h1-9,14H,10-11H2,\u003cbr\u003e\nInChiKey:LSONWRHLFZYHIN-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:2-[(4-phenoxyphenyl)sulfonylmethyl]thiirane\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMMP14 also known as MT1-MMP MMP2 and MMP9 are enzymes in the matrix metalloproteinase (MMP) family which are zinc-dependent endopeptidases. They play major role in degrading extracellular matrix proteins. MMP14 has a molecular mass of about 66 kDa and is expressed in various tissues including the brain and connective tissues. MMP2 often referred as gelatinase A weighs approximately 72 kDa while MMP9 or gelatinase B is around 92 kDa. Both MMP2 and MMP9 appear in many cell types like macrophages neutrophils and fibroblasts. Their expression promotes tissue remodeling and repair.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMMP14 MMP2 and MMP9 are significant in matrix remodeling processes. These proteins can form active complexes in presence of TIMPs (tissue inhibitors of metalloproteinases) regulating their activity. They break down not just structural proteins in extracellular matrix but also bioactive molecules impacting cellular functions such as migration invasion and angiogenesis. This biological activity of MMPs is critical in both physiological development and pathological processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nMMP14 MMP2 and MMP9 contribute significantly to the ECM-receptor interaction pathway and the PI3K-AKT signaling pathway. These pathways influence cell survival proliferation and migration. Additionally they relate to proteins like TIMP1 and TIMP2 that regulate their enzymatic activity. By integrating these pathways MMPs sustain important mechanisms in tissue homeostasis and pathological conditions such as tissue fibrosis and cancer progression.\u003cbr\u003e\nMMP14 MMP2 and MMP9 have strong associations with cancer and arthritis. These enzymes facilitate cancer invasion and metastasis by degrading surrounding tissue barriers often seen in a range of tumorigenic processes. In arthritis particularly rheumatoid arthritis their imbalance leads to enhanced cartilage degradation. Connecting to this role in disease are proteins like cytokines and growth factors that induce MMP expression further implicating them in disease etiology and progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847425609897,"sku":"ab141579","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab141579","provider":"Iright","version":"1.0","type":"link"}